{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"The BOB.1 protein is a co-activator that interacts with OCT-1 and/or OCT-2 transcription factors, and is critical in germinal center formation and immunoglobulin production. The strongest expression of BOB.1 is found in the germinal center, mantle-zone B cells, and plasma cells. BOB.1 is expressed in follicular center lymphomas, diffuse large B-cell lymphomas, and Burkitt lymphomas. B-CLL, MALT-type, and mantle cell lymphomas are negative or display a heterogenous/weaker expression."}]}]}