{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"BCOR or "},{"type":"text","value":"'"},{"type":"text","value":"Corepressor of BCL-6"},{"type":"text","value":"'"},{"type":"text","value":" is an epigenetic regulator that enhances BCL-6-mediated transcriptional repression, involved in the specification of cell differentiation and body structure development. Studies shown various BCOR aberrations, represent driver elements of various sarcomas such as clear cell sarcoma of the kidney, primitive mesenchymal myxoid tumor of infancy, small round blue cell sarcoma, endometrial stromal sarcoma and histologically heterogeneous central nervous system neoplasms group with similar genomic methylation patterns known as CNS-HGNET-BCOR. Furthermore, other BCOR alterations (often loss of function mutations) recur in a large variety of mesenchymal, epithelial, neural and hematological tumors."}]}]}