{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Bcl-10 (also known as B-cell lymphoma/leukemia 10) is a 233 amino acid protein encoded by the BCL10 gene on Chromosome 1. The protein encoded by this gene contains a caspase recruitment domain, and has been shown to induce apoptosis and activate NF-kappaB. This protein is reported to interact with caspase recruitment domains (CARD) containing proteins including CARD9, 10, 11 and 14. These proteins function as upstream regulators in NF-kappaB signaling. Studies have shown that Bcl-10 plays a critical role in the development of mucosa associated lymphoid tissue (MALT) lymphoma."}]}]}