{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"BAP1 or BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of highly conserved transcriptional repressors required for long-term silencing of genes that regulate cell fate determination, stem cell pluripotency, and other developmental processes. In cancer, BAP1 can function both as a tumor suppressor and as a metastasis suppressor."}]}]}