{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Genes encoding subunits of SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes are collectively mutated in 20% of all human cancers. ARID1A encodes a protein subunit of SWI/SNF chromatin remodeling complexes. ARID1A is a tumour suppressor gene and is most frequently mutated, at variable frequencies across molecular and histological subtypes of cancer. ARID1A influences the expression of many genes, including those involved in cell growth, differentiation, and DNA damage response."}]}]}