{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Annexin A1 inhibits the NF-kB signal transduction pathway (which is exploited by cancerous cells to proliferate and avoid apoptosis) by binding to the p65 subunit, and has been of interest for use as a potential anti-cancer drug. It may also contain tumor suppressive and protective characteristics, which have been evidenced by its ability to protect against DNA damage induced by heat in breast cancer cells. According to literature Annexin A1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of most hairy cell leukemia."}]}]}