{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Anaplastic lymphoma kinase (ALK), also known as CD246, is a receptor tyrosine kinase. ALK was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM-ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK. ALK gene fusion can occur with other genes too and are considered oncogenic drivers."}]}]}