{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Adipose differentiation-related protein, also known as perilipin 2 (PLIN2), ADRP or adipophilin, is a protein which in humans is encoded by the ADFP gene. This protein is associated with the globule surface membrane material and a major constituent of the globule surface. Increase in adipophilin mRNA levels is one of the earliest indications of adipocyte differentiation. Adipophilin occurs in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis."}]}]}