{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Adrenocorticotropic Hormone (ACTH or corticotropin) is a 39 residue polypeptide hormone synthesized from pro-opiomelanocortin (POMC) and secreted from corticotropes in the anterior pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. ACTH travels through the bloodstream to the adrenal glands to stimulate the release of cortisol. ACTH expression can be seen in the anterior pituitary gland and certain pituitary tumors."}]}]}