{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Tyrosinase is an enzyme that catalyzes the oxidation of phenols (such as tyrosine) and is widespread in plants and animals. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. The gene for Tyrosinase is regulated\n by the Microphthalmia-associated transcription factor. A mutation in the tyrosinase gene leads to impaired tyrosinase production resulting in Type I Oculocutaneous Albinism, a hereditary disease that affects 1 in 17,000 people in the U.S."}]},{"type":"paragraph","children":[{"type":"text","value":"Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as Malignant Melanoma and Melanotic Neurofibroma. Essentially no carcinomas express this marker."}]}]}