{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"p27KIP1 is a cell cycle regulatory mitotic inhibitor of Cdk activity. p27KIP1 is a candidate-tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 is up-regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as Cyclin D1/Cdk4. Low p27 expression has been associated with unfavorable prognosis in Renal-cell Carcinoma, Colon Carcinoma, Small Breast Carcinomas, Non-small-cell Lung Carcinoma, Hepatocellular Carcinoma, Multiple Myeloma, lymph node metastases in Papillary Carcinoma of the Thyroid, and a more aggressive phenotype of Carcinoma in the Cervix."}]}]}