{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Desmin is a type of intermediate filament found near the Z line in sarcomeres. Both vimentin and desmin are characteristics of mesenchymal cells."},{"type":"text","value":" Desmin antibody detects a protein that is expressed by cells of normal smooth, skeletal and cardiac muscles. Light microscopy studies of desmin suggests that it is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, Desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Desmin antibody reacts with Leiomyomas, Rhabdomyomas, and Perivascular cells of Glomus Tumors of the skin (if they are of myogenic nature). This antibody is used to demonstrate the myogenic components/derivation of tumors."}]}]}