{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cytokeratin 5 (58 kDa) is a high-molecular weight, basic type of cytokeratin expressed in basal, intermediate and superficial-cell layers of stratified epithelia as well as transitional epithelia, complex epithelia, mesothelial cells and Mesothelioma. Cytokeratin 6 (56 kDa) is also a high-molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16."}]},{"type":"paragraph","children":[{"type":"text","value":"CK 5 and 6 are positively seen in nearly 100% of Malignant Mesotheliomas and is rarely seen in Lung Adenocarcinomas. CK 5 and 6 can positively be seen in undifferentiated Large-cell Carcinoma as well as Squamous Carcinoma. Fewer than 10% of Carcinomas of the breast, colon, and prostate stain positively for this marker."}]},{"type":"paragraph","children":[{"type":"text","value":"CK 5 and 6 have also been used successfully as a myoepithelial cell marker in the prostate to determine."}]}]}