{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"OCT4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a protein that in humans is homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. Expression of the OCT4 is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. OCT4 is expressed in undifferentiated pluriopotency cells, germ cells in ovary and testes. OCT4 is a sensitive and specific marker for germ cell tumors. It is consistently detected in carcinoma in situ/gonadoblastoma, seminomas, germinoma, dysgerminoma, and embryonal carcinoma but not in the differentiated components of nonseminomas."}]}]}