{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is expressed in the central and peripheral nervous system and in many normal and pathological tissues. It stains Mesothelioma and can be used to help differentiate lung tumors. Calretinin is also considered an important diagnostic tool in the differential diagnosis of cystic and solid Ameloblastic Tumors."}]},{"type":"paragraph","children":[{"type":"text","value":"Anti-calretinin has been shown to be useful in differentiating Mesothelioma from Adenocarcinomas of the lung and other sources. It is also useful in differentiating adrenal-cortical neoplasms from Pheochromocytomas."}]}]}