{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"The trichorhinophalangeal syndrome 1 (TRPS-1) gene belongs to the GATA transcription factor family. TRPS-1 has been identified as a highly prevalent gene in Breast Cancer, expressed in >90% of estrogen receptor alpha (ERα)+ and ERα− BC subtypes."},{"type":"text","value":" As of today, the GATA3 tumor marker is commonly used to determine the breast origin for ER-positive and low-grade Breast Cancer, but is low in sensitivity <20% in metaplastic Breast Carcinoma such as Triple-Negative Breast Cancer (TNBC). In contrast, TRPS1 and GATA3 had comparable positive expression in ER-positive (98% vs. 95%) and HER2-positive (87% vs. 88%) Breast Carcinomas, but TRPS1 had higher expression than GATA3 in metaplastic (86% vs. 21%) and nonmetaplastic (86% vs. 51%) TNBC cases."},{"type":"text","value":" TCGA data indicated that the (TRPS1) is a specific gene for Breast Carcinoma across 31 solid tumor types, including all 4 subtypes of Breast Carcinoma such as ER/PR-positive luminal A and B types, HER2-positive type, and basal-type/TNBC. TRPS1 produced no or little expression in Lung, Pancreatic, Colon, or Gastric Adenocarcinomas, Urothelial, Renal, or Ovarian Carcinomas, or Melanoma; it can be concluded that the TRPS1 marker is a sensitive and specific marker for Breast Cancer and particularly for TNBC."}]}]}