{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lamin-B1 is an intermediate filament protein that in humans is encoded by the gene LMNB1. B-type Lamin along with A-type Lamin line the inner surface of the nuclear envelope and form a dynamic structure that is disassembled and reassembled each time a cell enters mitosis. Lamin-B1 plays a central role in chromatin organization, gene positioning, DNA replication and repair, cell cycle progression, stress responses, proliferation and differentiation."}]},{"type":"paragraph","children":[{"type":"text","value":"Lamin-B1 loss is associated with cellular senescence and a broad range of aging-related diseases such as cardiovascular diseases and cancers. Recent studies showed Lamin-B1 deficiency promotes Lung Cancer development and metastasis by epigenetic derepression of RET, as well as malignancy and poor prognosis in Gastric Cancer. It has been observed that Lamin B1 levels are reduced in Lung Cancer patients compared to normal Lung tissue and that lower expression of Lamin B1 was associated with higher tumor grade. The levels of lamin A, on the other hand, were not altered in human Lung Tumors, indicating that the different types of lamins have distinct functions in lung carcinogenesis. \n Overexpression of Lamin-B1 can also indicate poor prognosis in Colon and Pancreatic Cancers."}]}]}