{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Annexin VII (or Annexin A7) is a Ca2+-dependent and phospholipid-binding protein. It is encoded by the ANX7 gene, which is located in human chromosome 10q21. It is a member of the annexin protein family, which regulates various endomembrane processes including vesicle fusion, segregation, and compartmentalization and is implicated in plasma membrane repair mechanisms."}]},{"type":"paragraph","children":[{"type":"text","value":"Studies suggest that ANX7 is a tumor suppressor gene and it was found that Annexin VII is associated with several types of cancers, such as Prostate, Breast, Liver, and Gastric cancer. IHC analysis showed that a low or the loss of expression of ANX7 correlates with Prostate cancer progression. On the contrary, high levels of ANX7 expression were found in Metastatic Breast Tumors and that HER2-Negative patients suffer increased risk of death when ANX7 expression levels are elevated. Another study found that ANX7 predominantly shows low expression in other cancer types, such as Colon Adenocarcinoma or Bladder Transitional Cell Carcinoma. A study identified the prognostic impact of ANXA7 in Prostate Cancer using tissue microarrays, identified ANXA7 as a new prognostic factor and indicated a bimodal correlation to tumor progression. Another study concluded that Annexin A7 expression was able to inhibit HCC lymph node metastasis, whereas knockdown of Annexin A7 expression significantly induced HCC metastasis to local lymph nodes."}]}]}