{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"PLA2R1 gene encodes the phospholipase A2 receptor 1 protein, a 180 kDa transmembrane glycoprotein expressed by podocytes. Approximately 70% of patients with idiopathic membranous glomerulopathy have autoantibodies directed against PLA2R1. \n PLA2R1 also promotes tumor suppressive responses including senescence, apoptosis, and inhibition of transformation. Known oncogenes such as HIF2α and c-Myc repress PLA2R1 expression.\n Supporting a tumor suppressive role of PLA2R1, its expression decreases in numerous cancers, and known oncogenes such as HIF2α and c-MYC repress its expression. PLA2R1 promoter methylation, a classical way to repress tumor suppressive gene expression in cancer cells, is observed in leukemia, in the kidney and in breast cancer cells. Mechanistically, PLA2R1 activates the kinase JAK2 and orients its activity towards a tumor suppressive one. PLA2R1 also promotes accumulation of reactive oxygen species which induce cell death and senescence."}]}]}