{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes. TLEs associates with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation."}]},{"type":"paragraph","children":[{"type":"text","value":"Anti-TLE1 can be used to differentiate synovial sarcoma from other sarcomas, including histologically similar tumors such as malignant peripheral nerve sheath tumor."}]}]}