{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Villin is an actin-binding protein that contains gelsolin domains capped by a ”headpiece” consisting of a fast and independently-folding three-helix bundle stabilized by hydrophobic interactions. The headpiece domain is a commonly-studied protein in molecular dynamics due to its fast-folding kinetics and short primary sequence. It is a regulator of the actin cytoskeleton and is expressed mainly in the brush border of the GI mucosal epithelium in animals."}]},{"type":"paragraph","children":[{"type":"text","value":"Anti-Villin labels the brush border area in the gastrointestinal mucosal epithelium. This antibody has been useful in differentiating Gastrointestinal Adenocarcinoma, Neuroendocrine Carcinomas and Ovarian Adenocarcinomas from Adenocarcinomas of other organs. Also labeled by this antibody are Merkel cells of the skin."}]}]}