{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"PMS2 is a gene that encodes for DNA repair proteins involved in mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells."}]},{"type":"paragraph","children":[{"type":"text","value":"Along with MLH1, MSH2 and MSH6, PMS2 is helpful in diagnosing MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with none and tumors with high-level MSI."}]}]}