{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"HER-2 neu (also known as c-erbB-2) is a member of the epidermal growth factor receptor (EGFR) family and is notable for its role in the pathogenesis of breast cancer and as a target of treatment. It is a cell membrane surface-bound tyrosine kinase and is normally involved in the signal transduction pathways leading to cell\n growth and differentiation. HER-2 neu is a proto-oncogene located at the long arm of human chromosome 17(17q11.2-q12)."}]}]}