{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Octamer transcription factor-2 (OCT-2) possesses a leucine zipper domain and belongs to the POU family of transcription factors. It binds to the octamer motif (5-ATTTCAT-3), activates immunoglobulin gene expression and regulates transcription in a number of tissues. OCT-2 is important for the expression of B cell specific genes, such as CD20 and CRISP-3. OCT-2 is expressed in mature B cells, predominantly germinal center B cells."}]},{"type":"paragraph","children":[{"type":"text","value":"The OCT-2 antibody labels various B cell lymphomas with strong expression in germinal center-derived lymphomas."}]}]}