PIN MultiDetector HRP/AP Kit

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PIN MultiDetector HRP/AP Kit

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Size BSB-0352-7 PIN MultiDetector (CK 34BE12 p63 & AMACR 7 ml) AP & HRP (2 x 7 ml) & Chromogens 3 x 1 ml (70 Tests) BSB-0352-15 PIN MultiDetector (CK 34BE12 p63 & AMACR 15 ml) AP & HRP (2 x 15ml) & Chromogens 3 x 2 ml (150 Tests) BSB-0352-50 PIN MultiDetector (CK 34BE12 p63 & AMACR 50 ml) AP & HRP (2 x 50 ml) & Chromogens 3 x 6 ml (500 Tests)

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Product Information

Summary & Explanation

{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Prostate Intraepithelial Neoplasia (PIN) is a precancerous condition of the prostate glands with a high predictive value for adenocarcinoma. An estimated third of men over 50 have a latent form of PIN,which could develop into a higher grade and eventually malignant carcinoma. High Grade (≥2) PIN (HGPIN) has morphological and genetic similarityto prostate adenocarcinomas, and adenocarcinoma presence and multifocality may be associated with the size and number of HGPIN foci. It is well established that the IHC of p63 and CK34BE12 are expressed in basal cells of healthy prostate glands, but mostly absent in adenocarcinoma. AMACR (Alpha-Methylacyl CoA Racemase) is expressed in the glands and has been found to be highly expressed in prostate carcinoma and can help to distinguish PIN, a precursor lesion to Prostatic Adenocarcinoma, from benign lesions"}]},{"type":"paragraph","children":[{"type":"text","value":"\n\nThe Prostate Intraepithelial Neoplasia (PIN) MultiDetector HRP/AP Kit is a Multiplex triple color IHC Kit designed to detect prostate cancer in situ in the prostate glands. The basal cell indicators (myoepithelial cells with p63 stained with HRP DAB Brown and basal cells with CK34BE12 stained with AP/ ALK Scarlet) stain non-affected glands and the AMACR stained with HRP Green shows prostate tissue that may be affected by Prostatic Adenocarcinoma.\n\n"}]}]}

Materials and Presentation

The PIN MultiDetector HRP/AP Kit contains a p63 (4A4) MMab prediluted antibody, a CK34BE12 (34BE12) MMab and AMACR (13H4) RMab prediluted antibodycocktail, ImmunoRetriever with Citrate heat epitope retrieval solution, Peroxidase Blocker solution, AP Blocker solution, a Mouse MultiDetector HRP Label, a Mouse MultiDetector AP and Rabbit MultiDetector HRP cocktail solution, a DAB Buffer and DAB Chromogen solution, an ALK Scarlet Buffer and Scarlet Chromogen solution, an HRP Green Buffer and Chromogen solution, and a Fast ChromoProtector stain protection solution. All the components are buffered and contain proteins, stabilizers, and a non-azide antimicrobial.

Features	Catalog No.
	BSB-0352-7 7 mL Kit 70 Tests*	BSB-0352-15 15 mL Kit 150 Tests*	BSB-0352-50 50 mL Kit 500 Tests*
20X ImmunoRetriever with Citrate	✓ 50 mL	✓ 100 mL	✓ 200 mL
MultiDetector Peroxidase Blocker	✓ 7 mL	✓ 15 mL	✓ 100 mL
MultiDetector AP Blocker	✓ 7 mL	✓ 15 mL	✓ 100 mL
NGFR MAb & CK 5/6 MAb Cocktail	✓ 7 mL	✓ 15 mL	✓ 50 mL
Mouse MultiDetector HRP & Rabbit MultiDetector AP Label cocktail	✓ 7 mL	✓ 15 mL	✓ 50 mL
MultiDetector DAB Buffer-Substrate	✓ 7 mL	✓ 15 mL	✓ 100 mL
MultiDetector DAB Chromogen	✓ 1 mL	✓ 2 mL	✓ 6 mL
MultiDetector ALK Scarlet Buffer-Substrate	✓ 7 mL	✓ 15 mL	✓ 100 mL
MultiDetector Scarlet Chromogen	✓ 1 mL	✓ 2 mL	✓ 6 mL
20X ImmunoDNA Washer	✓ 50 mL	✓ 100 mL	✓ 200 mL
Fast ChromoProtector	✓ 10 mL	✓ 20 mL	✓ 50 mL
Control Slides	✓ 5 Slides	✓ 10 Slides	✓ 30 Slides