cd68 anti-cd68 antibody immunbohistochemistry ihc

CD68 Antibody Immunohistochemistry on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

The CD68 antigen is a heavily glycosylated transmembrane protein of 87-115 kDa which is specifically expressed by tissue macrophages, Langerhans cells and, at low levels, by dendriticcells. CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracel-lular cell-cell and cell-pathogen interactions.

CD68 antibody marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; Lymphomas are negative or show a few granules. This antibody may be useful for the identification of Myelomonocytic and Histiocytic Tumors. The CD68 antibody may help to distinguish Malignant Fibrous Histiocytoma from other Pleomorphic Sarcomas. However, since CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also produce positive results.

Antibody TypeMouse MonoclonalCloneBSB-8
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Lymph Node
PresentationCD68 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5288PredilutedReady-To-Use3.0 ml
BSB 5289PredilutedReady-To-Use7.0 ml
BSB 5290PredilutedReady-To-Use15.0 ml
BSB 5291Concentrated1:250-1:10000.1 ml
BSB 5292Concentrated1:250-1:10000.5 ml
BSB 5293Concentrated1:250-1:10001.0 ml
BSB 5294Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: CD68, Gp110, SCARD1, LAMP4, anti-CD68, anti CD68, anti-GP110, anti GP110, anti-LAMP4, anti LAMP4, anti-SCARD1, anti SCARD1, CD68 antigen, CD68 molecule, DKFZp686M18236, macrophage antigen CD68, macrosialin, scavenger receptor class D member 1