cd33 anti-cd33 antibody immunohistochemistry ihc

CD33 Antibody Immunohistochemistry on a FFPE Colon Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

CD33 (gp62 or siglec-3) is a glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family. The genomic locus of this protein has been mapped to chromosome 19q13.1-3.5. The function of CD33 is not known, but it may have a role in cell-to-cell adhesion. In maturing granulocytic cells, there is progressive down-regulation of CD33 from the blast stage to mature neutrophils. However, in monocytes and macrophages/histiocytes, strong expression of CD33 is maintained throughout maturation.

Detection of CD33 using monoclonal antibodies has been a critical component in immunophenotyping acute leukemias, particularly Acute Myeloid Leukemias.

Antibody TypeRabbit MonoclonalCloneRBT-CD33
IsotypeIgGReactivityParaffin, Frozen
LocalizationMembranousControlPlacenta, Myometrium, Lung, Colon, Spleen, Lymph Node, Tonsil, Acute Myeloid Leukemia
PresentationCD33 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3448PredilutedReady-To-Use3.0 ml
BSB 3449PredilutedReady-To-Use7.0 ml
BSB 3450PredilutedReady-To-Use15.0 ml
BSB 3451Concentrated1:10-1:500.1 ml
BSB 3452Concentrated1:10-1:500.5 ml
BSB 3453Concentrated1:10-1:501.0 ml
BSB 3454Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: CD33 antigen gp67, CD33 molecule, FLJ00391, gp67, Myeloid cell surface antigen CD33, p67, sialic acid binding Ig like lectin 3, Siglec 3, SIGLEC3, anti-cd33, anti cd33