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Published Works and White Papers
| BioSB | Publications | Link |
| ELSEVIER | HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways | |
| Journal of Clinical Research and Case Studies | Development and validation of antibodies against SARS CoV-2 by immunohistochemistry to assess the pathogenesis of COVID-19 and its role in Cytokine Storm Syndrome and coagulopathy. | |
| Journal of Pathology Research Reviews & Reports | Relevance and Limitations in the Expression of Immunotherapy IHC Markers in Penile Cancer (HPV Male Vaccine). An Outcome in Evolution | |
| Viruses | Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case? | |
| Nature Methods | MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging | |
| Human Pathology | “Severe placental lesions due to maternal SARS-CoV-2 infection associated to intrauterine fetal death | |
| Cancer Cell | Immunogenomic Landscape of Hematological Malignancies | |
| Pathogens | Association between Toxoplasma gondii Infection in Brain and a History of Depression in Suicide Decedents: A Cross-Sectional Study | |
| Clinical Cancer Investigation Journal | Evaluation of the Diagnostic Value of Immunohistochemistry Staining for P63, Alpha‑methyl Acyl‑CoA Racemase, CK5/6, and 34βE12 in Prostate Carcinoma | |
| Journal of Pathology and Translational Medicine | PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms | |
| ResearchGate | Smartphone-based early detection of viral pathogens including SARS-CoV-2 with Sensitivities exceeding 98.7% and a specificity nearing 100%. | |
| Sonora Star | BIO SB, Estudia Bio SB la predisposición genética para desarrollar COVID-19 | Website |
| Walpole & Co., LLP | Focusing on Our Clients: Dr. Alfonso Heras, Bio SB President and CEO | |
| Walpole & Co., LLP | Focusing on our Clients: Bio SB – Bioscience for the world | Website |
| Santa Barbara News Press Publication | Santa Barbara biotech company working on technologies: Learning more about COVID-19 | Website |
| c1Qc White Paper using Bio SB p16 Antibodies | Canadian IHC Quality Control Run with p16 for Immunohistochemistry | |
| Sonora Star Interview with Dr. Alfonso Heras | BIO SB, empresa de origen sonorense que aporta a la investigación, ciencia y diagnóstico del cáncer a nivel mundial | Website |
| PolyDetector Plus HRP/DAB for Mohs applications on frozen tissues | Rapid SOX10 Immunostain on Fresh Frozen Tissue | |
| Multiplex IHC using Bio SB Antibodies | Multiplex immunohistochemistry accurately defnes the immune context of metastatic melanoma: Using Bio SB Antibodies for Mulitplex IHC | Scientific Reports |
| NSH Podcast: Automated 5 Minute Mohs IHC | This podcast is part of the 2017 NSH Symposium/Convention Poster Podcast Series | MP3 |
| Automated 5 Minute Mohs IHC | Reporting the use of a highly sensitive monovalent Fab anti‐mouse and anti‐rabbit micropolymer IHC detection system for the detection of antibodies for melanoma, MART‐1, SOX‐10, BCC and SCC using a compact automated IHC stainer | |
| Solvent Free Environmentally Friendly IHC | Reporting the use of a new generation of heat assisted 3-in-1 one-step deparaffinization, retrieval and hydration solutions and their protocols | |
| ALK/EML4 Tricheck FISH | Validation of a simplified approach to detect ALK translocations in lung cancer samples by FISH | |
| Hydrophilic Plus Slides | See how Bio SB Hydrophilic Plus Slides prevent tissue detachment | |
| Topo IIα, MCM2 & p16 on Cervix | Immunohistochemical Expression of p16, MCM2, Topo IIα and MCM2/Topo IIα cocktail in Cervical Squamous Intraepithelial Lesions | |
| PubMed Results for Bio SB | See all publications of PubMed that list Bio SB |
| Product | Descriptions | Link |
| ImmunoDetector HRP/DAB | Importance of p16 and Ki67. Immunohistochemical Expression and in a Typical Immature Metaplasia (AIM) | |
| CD8 (BSB 5174) | Systems pathology by multiplexed immunohistochemistry and whole slide digital image analysis | |
| Immuno-Block reagent | Combination therapy with extracorporeal shock wave and melatonin markedly attenuated neuropathic pain in rat | |
| Immuno-Block reagent | Combination therapy of exendin-4 and allogenic adipose-derived mesenchymal stem cell preserved renal function in a chronic kidney disease and sepsis syndrome setting in rats | |
| PolyDetector HRP Detection System | Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fbrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells | |
| Immuno-Block reagent | Therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced fatty liver disease, fibrosis and inflammation in rabbit | |
| Immuno-Block reagent | Effective protection against acute respiratory distress syndrome/sepsis injury by combined adipose-derived mesenchymal stem cells and preactivated disaggregated platelets | |
| Immuno-Block reagent | Exendin-4-assisted adipose derived mesenchymal stem cell therapy protects renal function against co-existing acute kidney ischemia-reperfusion injury and severe sepsis syndrome in rat | |
| Immuno-Block reagent | DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning | |
| Immuno-Block reagent | Extracorporeal shock wave treatment attenuated left ventricular dysfunction and remodeling in mini-pig with cardiorenal syndrome | |
| Immuno-Block reagent | Impact of impaired cardiac function on the progression of chronic kidney disease—role of pharmacomodulation of valsartan | |
| Immuno-Block reagent | Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis | |
| Immuno-Block reagent | Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury | |
| Mouse/Rabbit PolyDetector Plus HRP/DAB | Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model | |
| PD-L1 (PD-L1/CD274) | PD-L1/PD-1 check-point in gastric carcinoma with lymphoid stroma case report with immunochemical study | |
| Immuno-Block reagent | Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome | |
| c-Kit, Inhibin, S100, CD56, Chromogranin, Synaptophysin, CD99, PAX5, GATA3 |
Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation | |
| 11-core TMA (BSB 0297), Polydetector Detection Systems | Extending Whole Slide Imaging: Color Darkfield Internal Reflection Illumination (DIRI) for Biological Applications | |
| Background Blocker (BSB 0105), mouse/rabbit immunodetector HRP LABEL, mouse/rabbit immune detector biotin link (BSB 0005) |
Effect of moderate and high intensity chronic exercise on the pancreatic islet morphometry in healthy rats: BDNF receptor participation | |
| Immuno-Block reagent | Circulating microparticles enhanced rat vascular wall remodeling following endothelial denudation | |
| pancytokeratin and P63 (clone 4A4, BIOSB, 1/100) | Angiosarcoma: A Case Report of Gingival Disease with Both Palatine Tonsils Localization | |
| PolyDetector AP Blocker (BSB 0055), hematoxylin (BSB 0024) | Molecular profiling of a simple rat model of open tibial fractures with hematoma and periosteum disruption | |
| FITC conjugated polyclonal rabbit antibodies, IgG, IgM, IgA, C3, C1 , kappa, and lambda |
Immunofluorescence on paraffin embedded renal biopsies: Experience of a tertiary care center with review of literature | |
| immunoDNA Retriever | Differential proteins among normal cervix cells and cervical cancer cells with HPV-16 infection, through mass spectrometry-based Proteomics (2D-DIGE) in women from Southern México | |
| PolyDetector Peroxidase Block quenching buffer, DAB chromogen | The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b+Gr1+ Cells in a Transgenic Mouse Model | |
| Mouse/rabbit ImmunoDetector HRP DAB detection System | Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms | |
| mouse/rabbit polydetector peroxidase block, mouse/rabbit polydetector HRP | Enhancement of Wound Healing by Non-Thermal N2/Ar Micro-Plasma Exposure in Mice with Fractional-CO2-Laser-Induced Wounds | |
| immunoretriever | Zika virus damages the human placental barrier and presents marked fetal neurotropism | |
| Immuno-Block reagent, CD14 | Combined Therapy With Adipose-Derived Mesenchymal Stem Cells and Ciprofloxacin Against Acute Urogenital Organ Damage in Rat Sepsis Syndrome Induced by Intrapelvic Injection of Cecal Bacteria | |
| Immuno-Block reagent | Enhanced protection against renal ischemia–reperfusion injury with combined melatonin and exendin-4 in a rodent model | |
| S100 | Gynaecological Perspective of Schwannoma: A Rare Pelvic Tumour | |
| Immuno-Block reagent | Human lung cancer-derived microparticles enhanced angiogenesis and growth of hepatoma cells in rodent lung parenchyma | |
| ImmunoDNA Retriever with citrate | Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy | |
| Immuno-Block reagent | Extracorporeal shock wave therapy effectively prevented diabetic neuropathy | |
| TRACP | Association of Tartrate-Resistant Acid Phosphatase-Expressed Macrophages and Metastatic Breast Cancer Progression | |
| rabbit/mouse HRP-DAB polymer detection, hematoxylin | The repair of full-thickness articular cartilage defect using intra-articular administration of N-acetyl-d-glucosamine in the rabbit knee: randomized controlled trial | |
| Bio SB ImmunoDetector, Digital Pressure Cooker, Mouse/Rabbit Immunodetector HRP/DAB, Toxoplasma gondii, Toxoplasma gondii positive control slides |
Prevalence of Toxoplasma gondii Infection in Brain and Heart | |
| CD31 – MMab | Extracorporeal shock wave attenuates brain infarct volume – improves neurological function in rat after acute ischemic stroke – American Journal of Translational Medicine | |
| ImmunoBlock Reagent & CD31 | Peripheral blood-derived endothelial progenitor cell therapy prevented detrioriation of chronic kidney disease in rats | |
| TintoRetriever Pressure Cooker | Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function | |
| Mouse/Rabbit Polydetector HRP/DAB Detection System | Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling – Oncotarget | |
| Immuno-Block reagent | Mixed serum-deprived and normal adipose-derived mesenchymal stem cells against acute lung ischemia-reperfusion injury in rats | |
| Background Blocker, immune-Detector Biotin-Link and Immuno-Detector HRP label |
Chronic Excersise Increases Brain Derived Factor Levels, Pancreatic Islet Size and Insulin Tolerance in a TrkB-dependent manner | |
| Immuno-Block Reagent | Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors – APS | |
| Mast Cell Tryptase | Comparison of Mast Cells and Inflammatory Cells within Periapical Lesions and Comparison of Degranulated Mast Cells Between Fibrous and Inflamed Area in Radicular Cysts | |
| Chromogranin A | A Unique Case of Merkel Cell Carcinoma with Ovarian Metastasis | |
| ImmunoBlock Reagent | Extracorporeal shock wave therapy ameliorates cyclophosphamide induced rat acute interstitial cystitis – American Journal of Tranlastional Research | |
| Polydetector, diaminobenzidine | Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-κβ and caspase-3 | |
| Immuno-Block reagent | Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury | |
| ImmunoDetector Peroxidase Blocker | In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors | |
| anti-CD1a & anti-Factor XIIIa | Pro-inflammatory, Th1, Th2, Th17 Cytokines and Dendritic Cells: Pro-A Cross-Sectional Study in Chronic Periodontitis | |
| VEGF Receptor Type II | Olmesartan Potentiates the Anti-Angiogenic Effect of Sorafenib in Mice Bearing Ehrlich’s Ascites Carcinoma: Role of Angiotensin | |
| Immuno-Block reagent | Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats | |
| Pressure cooker, antigen retrieval solution (EDTA) | Lipoprotein Lipase (LPL) is Associated with Neurite Pathology and Its Levels Are Markedly Reduced in the Dentate Gyrus of Alzheimer’s Disease Brains | |
| Androgen Receptor (AR) MMab | The prognostic significance of loss of the androgen receptor and neuroendocrine differentiation in prostate biopsy specimens among castration-resistant prostate cancer patients | |
| Calponin (BSB5/20) | Myoepithelioma breast: clinically masquerading as breast carcinoma | |
| Immuno Retriever | Neuroendocrine cells are present in the domestic fowl ovary | |
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DAB, Immunodetector Peroxidase Blocker, Progesterone Receptor (PR), Immuno-Detector Biotin-Link, Immuno-Detector HRP label |
Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy | |
| PolyDetector Kit | Differential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model | |
| Bio SB Mouse/Rabbit PolyDetector | Combination of cilostazol and clopidogrel Attenuates Rat Critical Limb Ischemia | |
| Bio SB ImmunoDetector | Nuclear Expression of Rac1 in Cervical Premalignant Lesions and Cervical Cancer Cells | |
| RBT-HER2, PolyDetector HRP System | Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer | |
| ImmunoDetector HRP/DAB Kit |
Phase II trial of temsirolimus in patients with metastatic breast cancer – HHS Public Access |
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| Antigen Unmasking Solution | Histomorphometric and immunohistochemical analysis of infectious agents – Diagnostic Pathology | |
| Immuno/DNA Retriever |
Dual Inhibition of VEGFR and EGFR is an Effective Chemopreventive Strategy in the Mouse 4-NQO Model of Oral Carcinogenesis |
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| CD20 & Cyclin D1 | Well-differentiated (Marschalko-type) Plasmacytoma Resembling Thyroid Follicular Structures PDF | |
| ALK/EML4 Tricheck | ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer. | |
| ALK/EML4 Tricheck vs Abbott Vysis ALK | ALK/EML4 confirms positive results in anaplastic lymphoma cases | |
| ALK/EML4 Tricheck | Amplification but not translocation of anaplastic lymphoma kinase is a frequent event in oesophageal cancer | PubMed |
| ALK/EML4 Tricheck | Epidemiology of EML4–ALK translocations in a small, German non-small-cell lung cancer patient cohort | Future Medicine |
| ALK/EML4 Tricheck | EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations | |
| PCR | PCR Kits for HIV-2 Infections | |
| Real-Time PCR | Real-Time PCR Primer Systems for E.Coli | |
| Real-Time PCR | PCR Real-Time PCR Primer Systems for Rapid Detection of Human Viruses | |
| Bio SB Mouse/Rabbit PolyDetector | Biotin-free systems provide stronger immunohistochemical signal in oestrogen receptor evaluation of breast cancer | |
| CD34, PCNA & hTERT on Pituitary | Study of the telomerase hTERT fraction, PCNA and CD34 expression on pituitary adenomas. Association with clinical and demographic characteristics. | |
| hTERT on Prostate Cancer | Human telomerase and α-methylacyl-coenzyme A racemase in prostatic carcinoma. A comparative immunohistochemical study |