IHC of Synaptophysin on a FFPE Pancreas Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Synaptophysin is a synaptic vesicle glycoprotein weighing 38 kDa. It consists of four transmembrane domains and the protein is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. This antibody identifies both normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely-granular cytoplasmic staining is observed and probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers making synaptophysin an independent broad-range marker of neural and neuroendocrine differentiation. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | RBT-Synaptophysin | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Pancreas, Brain, Pituitary, Adrenal, Colon | |||||||||||||||||||||||||||||||||
| Presentation | Synaptophysin is a rabbit monoclonal antibody for immunohistochemistry derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||