SOX-2 Antibody Immunohistochemistry on an FFPE Brain Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

SRY (sex determining region Y)-box 2, also known as SOX-2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. It is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach.

SOX-2 antibody is expressed in fetal brain and is used as a marker for multipotential neural stem cells. In tumors, SOX-2 expression is observed in teratoma of the central nervous system, melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and squamous cell carcinoma of the gastrointestinal tract. SOX-2 may be useful in the identification of embryonal carcinoma. In stage I lung adenocarcinomas, SOX2 seems to be an independent predictor of poor outcome and may help stratify patients at increased risk for recurrence.

Antibody TypeRabbit MonoclonalCloneEP103
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlBrain, Oligodendroglioma, Squamous Cell Carcinoma
PresentationAnti-SOX-2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2202PredilutedReady-To-Use3.0 ml
BSB 2203PredilutedReady-To-Use7.0 ml
BSB 2204PredilutedReady-To-Use15.0 ml
BSB 2205Concentrated1:50-1:2000.1 ml
BSB 2206Concentrated1:50-1:2000.5 ml
BSB 2207Concentrated1:50-1:2001.0 ml
BSB 2208Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: Sox2, anti-sox-2, anti-sox2, sox 2, sox-2, anti sox-2, Sox 2,anti Sox 2, anti Sox-2, anti Sox2, anti SRY-related HMG-box transcription factor 2, anti-Sox 2, anti-Sox-2, anti-Sox2, anti-SRY-related HMG-box transcription factor 2, SRY-related HMG-box transcription factor 2, ANOP3, MCOPS3, MGC2413, SRY sex determining region Y box 2, SRY related HMG box gene 2, transcription factor SOX 2, transcription factor SOX2