SOX-11 Antibody Immunohistochemistry on an FFPE Mantle Cell Lymphoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Transcription factor SOX-11 is a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and plays a role in tumorigenesis and adult neurogenesis. SOX-11 antibody is normally expressed in the developing human central nervous system, medulloblastoma, and glioma. SOX-11 antibody nuclear expression is highly associated with both cyclin D1- positive and negative mantle cell lymphomas, with a stronger and more homogeneous Immunostain than cyclin D1. Absence of SOX-11 expression in mantle cell lymphoma (MCL) may be a characteristic of indolent MCL. Sensitivity and specificity for combined SOX-11 and cyclin D1 immunohistostaining in the diagnosis of cutaneous mantle cell lymphoma are both 100%. SOX-11 has also been detected in rare cases of Burkitt lymphoma, lymphoblastic lymphoma and T cell prolymphocytic leukemia and overexpression can be seen in malignant gliomas. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | CL0142 | |||||||||||||||||||||||||||||||||
| Isotype | IgG2a | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | Control | Mantle Cell Lymphoma | |||||||||||||||||||||||||||||||||
| Presentation | SOX-11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||