sdhb, ant-sdhb, anti sdhb, Iron sulfur subunit of complex II, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase ubiquinone iron sulfur subunit mitochondrial, succinate dehydrogenase complex subunit B iron sulfur Ip, antibody mouse monoclonal for immunohistochemistry IHC

SDHB Antibody Immunohistochemistry on a FFPE Hepatocellular Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

SDHB is a new mouse monoclonal antibody for immunohistochemistry from Bio SB. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene. The gene that codes for the SDHB protein is nuclear, not mitochondrial DNA. However, the expressed protein is located in the inner membrane of the mitochondria.  Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutation in this protein is associated with wide range of diseases such as Renal Cell Carcinoma, Paraganglioma, Gastrointestinal Stromal Tumors (GISTs), Pituitary Adenoma, and many others.

Mutations in the tumor suppressor genes SDHB, SDHC, and SDHD (or collectively SDHx) cause the inherited paraganglioma syndromes, characterized by pheochromocytomas and paragangliomas. The IHC for SDHB is negative in all SDH mutated paragangliomas regardless of whether the B, C or D subunit is involved. However, other tumors have been associated with SDHx mutations, such as Gastrointestinal Stromal Tumors, specifically in the context of Carney-Stratakis syndrome. It has been shown that SDHB immunohistochemistry is a reliable technique for the identification of pheochromocytomas and paragangliomas caused by SDHx mutations. It’s been shown that Carney-Stratakis syndrome- and Carney-triad-associated GISTs are negative by immunohistochemistry for SDHB in contrast to KIT- or PDGFRA-mutated GISTs and a majority of sporadic GISTs, and it has been suggested that GISTs of epithelioid cell morphology are tested for SDHB immunohistochemically

Antibody Type Mouse Monoclonal Clone BSB-131
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Breast, Adrenal, Prostate, Kidney, Spleen, Tonsil, Breast Carcinoma, Hepatocellular Carcinoma, Lung Adeno Carcinoma, Prostate Carcinoma, Papillary Thyroid Carcinoma
Presentation Anti – SDHB is a mouse monoclonal antibody for immunohistochemistry derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB-2375-3 Tnto Predilute Ready-To-Use 3.0 ml
BSB-2375-7 Tinto Predilute Ready-To-Use 7.0 ml
BSB-2375-15 Tinto Predilute Ready-To-Use 15.0 ml
BSB-2375-01 Concentrate 1:50-1:200 0.1 ml
BSB-2375-05 Concentrate 1:50-1:200 0.5 ml
BSB-2375-1 Concentrate 1:50-1:200 1.0 ml
BSB-2375-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: ant-sdhb, anti sdhb, Iron sulfur subunit of complex II, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase ubiquinone iron sulfur subunit mitochondrial, succinate dehydrogenase complex subunit B iron sulfur Ip
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