Myoglobin Antibody Immunohistochemistry on an FFPE Skeletal Muscle Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Myoglobin is a single-chain globular protein of 153 amino acids, containing a heme (iron-containing porphyrin) prosthetic group in the center around which the remaining apoprotein folds. With a molecular weight of 16.7 kDa, Myoglobin is the primary oxygen-carrying pigment of muscle tissues. Immunostaining with Myoglobin antibody provides a specific, sensitive and practical procedure for the identification of Rhabdomyosarcoma. Since myoglobin is found exclusively in skeletal and cardiac muscle, it may be used to distinguish Rhabdomyosarcoma from other soft-tissue tumors. Myoglobin antibody staining is also useful when demonstrating rhabdomyoblastic differentiation in other tumors, e.g., Neurogenic Sarcomas and Malignant Mixed Mesodermal Tumors of the uterus and ovary. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP87 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Skeletal Muscle Tissue | |||||||||||||||||||||||||||||||||
| Presentation | Myoglobin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
