{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in"}]},{"type":"paragraph","children":[{"type":"text","value":"the recruitment of other DNA replication proteins. MCM3 is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.\n Increased expression of MCM3 has been demonstrated in various tumors by immunohistochemistry and is used as a marker for tumor progression."}]}]}