igg4 anti-igg4 antibody immunohistochemistry ihc

IgG4 Antibody Immunohistochemistry on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4 antibody positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma.

Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4 antibody related sclerosing disease not only exhibits significantly more IgG4- positive plasma cells in affected tissues but also significantly higher IgG4/ IgG ratios (typically 30%).

Antibody TypeRabbit MonoclonalCloneEP138
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlColon, Tonsil, Spleen
PresentationIgG4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6814PredilutedReady-To-Use3.0 ml
BSB 6815PredilutedReady-To-Use7.0 ml
BSB 6816PredilutedReady-To-Use15.0 ml
BSB 6817Concentrated1:50-1:2000.1 ml
BSB 6818Concentrated1:50-1:2000.5 ml
BSB 6819Concentrated1:50-1:2001.0 ml
BSB 6820Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: IGHG4, Ig gamma 4 chain C region, immunoglobulin heavy constant gamma 4 G4m marker, anti-igg4, anti igg4