granzyme b anti-granzyme b anti-granzyme-b antibody immunohistochemistry ihc

Granzyme B Antibody Immunohistochemistry on an FFPE Spleen Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Granzymes are exogenous serine proteases that are released by cytoplasmic granules within cytotoxic T-cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.

Granzyme B antibody has been useful in diagnosing Natural Killer/T-cell Lymphoma, as well as Anaplastic Large Cell Lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s Disease.

Antibody TypeRabbit MonoclonalCloneEP230
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic (Granular)ControlLiver, Testis, Cervix, Tonsil, Lymph Node, Spleen
PresentationGranzyme B is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2405PredilutedReady-To-Use3.0 ml
BSB 2406PredilutedReady-To-Use7.0 ml
BSB 2407PredilutedReady-To-Use15.0 ml
BSB 2408Concentrated1:25-1:1000.1 ml
BSB 2409Concentrated1:25-1:1000.5 ml
BSB 2410Concentrated1:25-1:1001.0 ml
BSB 2411Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: anti-granzyme b, anti granzyme b, anti-gb, anti gb, GZMB, granzyme B granzyme 2 cytotoxic T lymphocyte associated serine esterase 1, CCPI, CGL 1, CGL1, CSP B, CSPB, CTLA1, CTSGL1, HLP, SECT