{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Galectin-3 is a 31 kDa beta-galactosidase binding lectin. It has been associated with binding to the basement membrane glycoprotein laminin. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins."}]},{"type":"paragraph","children":[{"type":"text","value":"Anti-Galectin-3 has been demonstrated to be valuable in differentiating between benign and malignant thyroid neoplasms in both histologic sections and Fine Needle Aspiration Biopsy material. Anti-Galectin-3 antibody has also been useful in identifying Anaplastic Large Cell Lymphoma."}]}]}