{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cytokeratin 8, also known as type II cytoskeletal 8, is a protein that is often paired with Cytokeratin 18. They are perhaps the most commonly found products of the intermediate filament gene family, and are expressed in single-layer epithelial tissues of the body. Cytokeratin 8 is an intermediate filament protein produced early in embryogenesis."}]},{"type":"paragraph","children":[{"type":"text","value":"Anti-Cytokeratin 8 can be used to detect Adenocarcinomas with simple epithelium origin. It can be used to distinguish between Duct (peripheral staining) from Lobular (perinuclear staining) Breast Carcinoma."}]}]}