{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CITED1 is a transcriptional coactivator of the p300/CBP-mediated transcription complex. It enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. It also stimulates estrogen-dependent transactivation activity mediated by estrogen receptor signaling by stabilizing the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. CITED1 also positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex, and associates with chromatin to the estrogen-responsive TGF-alpha promoter region in an estrogen-dependent manner.\n Additionally, CITED1 induces transcription from estrogen-responsive promoters and protection against cell death in Breast Cancer, potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter, and acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. Current investigations suggest that it may have a role in pigmentation of melanocytes."}]}]}