CD21 Antibody Immunohistochemistry on an FFPE Tonsil Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD21, also known as CR2, complement component (3d/Epstein Barr virus) receptor 2, is an integral membrane glycoprotein of molecular weight 140 kDa, involved in the complement system. CD21 binds to C3d. B-cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation. Complement component receptor-2 (CR2) is the membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. CD21 antibody is useful in the identification of follicular dendritic cell matrixes found in normal lymph nodes and tonsillar tissue. This antibody also labels Follicular Dendritic Cell Tumor/Sarcomas. The antigen is absent on T-lymphocytes, monocytes, and granulocytes. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP64 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous | Control | Tonsil, Lymph Node, Spleen | |||||||||||||||||||||||||||||||||
| Presentation | CD21 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
| Availability |
| |||||||||||||||||||||||||||||||||||
| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
| * The CD21 antibody, clone EP64, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409. | ||||||||||||||||||||||||||||||||||||
