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Immunohistochemistry (definition): the method for localizing specific antigens in tissue or cells using antibodies, enzyme conjugates and substrate-chromogens. The antigen-antibody reaction can be evidenced with an optical microscope. The antibodies can be polyclonal or monoclonal (usually from mouse or rabbit) in origin. These non-infectious biological reagents are used by research and clinical laboratories to detect the presence of infectious agents, cancer and other proteins of interest.