{"title":"Fast Mohs IHC","description":"","products":[{"product_id":"pi3772","title":"TintoFast Adipophilin","description":"\u003cp\u003eAdipose differentiation-related protein, also known as Perilipin 2 (PLIN2), ADRP or Adipophilin, is a protein which in humans is encoded by the ADFP gene. Adipophilin is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation. Adipophilin is present in a wide range of cultured cell lines, including fibroblasts, endothelial, and epithelial cells. In tissues, however, expression of Adipophilin is restricted to certain cell types, such as Lactating Mammary epithelial cells, Adrenal Cortex cells, Sertoli and Leydig cells of the male reproductive system, and Steatosis or fatty change hepatocytes in alcoholic liver Cirrhosis.\u003c\/p\u003e\n\n\u003cp\u003eAdipophilin expression in various Sebaceous lesions and other Cutaneous Tumors with a clear cell histology that may mimic sebaceous differentiation. Adipophilin can be valuable in an immunohistochemical panel when evaluating cutaneous lesions with clear cell histology as it identifies intracytoplasmic lipid vesicles in Sebaceous and Xanthomatous lesions. In periocular lesions, it is effective in helping to exclude Basal Cell Carcinoma and Squamous Cell Carcinoma when sebaceous carcinoma is under consideration. Adipophilin expression is not as useful for the differential diagnosis that includes Metastatic Renal Cell Carcinoma, a rare but important, diagnostic differential.\u003c\/p\u003e\n\n\u003cp\u003eThe pattern of adipophilin reactivity is important to observe as membranous vesicular staining is suggestive of intracellular lipids whereas granular cytoplasmic reactivity is not. Adipophilin is suitable for immunostaining and is helpful in the identification of intracytoplasmic lipids, as seen in Sebaceous lesions. It is especially helpful in identifying intracytoplasmic lipid vesicles in poorly differentiated Sebaceous Carcinomas in challenging cases such as small periocular biopsy specimens.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3772-3,3.0 mL,Predilute","offer_id":49735813562608,"sku":"BSB-3772-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3772-7,7.0 mL,Predilute","offer_id":49735813595376,"sku":"BSB-3772-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3772-15,15.0 mL,Predilute","offer_id":49735813628144,"sku":"BSB-3772-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3772.jpg?v=1778848783"},{"product_id":"pi3690","title":"TintoFast Androgen Receptor","description":"\u003cp\u003eThe androgen receptor (AR) is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone. The main function of the androgen receptor is as a DNA-binding transcription factor which regulates gene expression. However, the androgen receptor has additional functions independent of DNA binding. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and the brain.\u003c\/p\u003e\n\n\u003cp\u003eThis antibody reacts with the androgen receptor and also with the newly-described A form of the receptor. This antibody does not cross-react with estrogen, progesterone or glucocorticoid receptors. Abnormalities in the AR-signaling pathway have been linked to a number of diseases, including Prostate Cancer, Kennedy’s Disease and male infertility.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3690-3,3.0 mL,Predilute","offer_id":49735813693680,"sku":"BSB-3690-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3690-7,7.0 mL,Predilute","offer_id":49735813726448,"sku":"BSB-3690-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3690-15,15.0 mL,Predilute","offer_id":49735813759216,"sku":"BSB-3690-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3690.jpg?v=1778848845"},{"product_id":"pi3691","title":"TintoFast CD31","description":"\u003cp\u003eCD31 is also called PECAM-1 for platelet endothelial cell-adhesion molecule. It plays a key role in removing aged neutrophils from the body. CD-31 is normally found on stem cells, endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T\/NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts and neutrophils. CD-31 is also expressed in certain tumors, including Epithelioid Hemangioendothelioma, Epithelioid Sarcoma like Hemangioendothelioma, other vascular tumors, Histiocytic malignancies, and Plasmacytomas. It is rarely found in some sarcomas and carcinomas. CD-31 and macrophages play a key role in tissue regeneration.\u003c\/p\u003e\n\n\u003cp\u003eCD31 is widely used to identify the vascular origin of neoplasms, as it is a highly specific and sensitive marker for vascular endothelial cells.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3691-3,3.0 mL,Predilute","offer_id":49735813857520,"sku":"BSB-3691-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3691-7,7.0 mL,Predilute","offer_id":49735813890288,"sku":"BSB-3691-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3691-15,15.0 mL,Predilute","offer_id":49735813923056,"sku":"BSB-3691-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3691.jpg?v=1778848924"},{"product_id":"pi3773","title":"TintoFast Chromogranin A","description":"\u003cp\u003eChromogranin A is a member of the chromogranin\/secretogranin family of neuroendocrine secretory proteins. Examples of cells producing chromogranin A are the adrenal medulla, enterochromaffin-like cells and beta cells of the pancreas. The function of chromogranin A is unknown but it is a precursor to 3 functional peptides: vasostatin, pancreastatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine).\u003c\/p\u003e\n\n\u003cp\u003eChromogranin A is an excellent marker for Carcinoid Tumors, Pheochromocytomas, Paragangliomas, and other Neuroendocrine Tumors. Coexpression of Chromogranin A and Neuron-Specific Enolase (NSE) is common in Neuroendocrine Neoplasms. It has been identified in a wide variety of endocrine tissues including the Pituitary, Pancreas, Hypothalamus, Thymus, Thyroid, Intestine and Parathyroid. It is generally accepted that the coexpression of certain Keratins and Chromogranin means Neuroendocrine lineage. The presence of strong Chromogranin staining and absence of Keratin staining should raise the possibility of Paraganglioma. Most Pituitary Adenomas and Prolactinomas readily express Chromogranin.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3773-3,3.0 mL,Predilute","offer_id":49735814021360,"sku":"BSB-3773-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3773-7,7.0 mL,Predilute","offer_id":49735814054128,"sku":"BSB-3773-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3773-15,15.0 mL,Predilute","offer_id":49735814086896,"sku":"BSB-3773-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3773.jpg?v=1778848970"},{"product_id":"pi3671","title":"TintoFast CK7","description":"\u003cp\u003eCytokeratin 7 (CK7) reacts with proteins that are found in the most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 distinguishes between lung and breast epithelium that stain positive, and colon and prostate epithelial cells that are negative.\u003c\/p\u003e\n\n\u003cp\u003eThis antibody also reacts with many benign and malignant epithelial lesions (e.g., Adenocarcinomas of the ovary, breast and lung). Further, in frozen sections, the antibody has been shown to label the rete epithelium in the testis, epididymis epithelium, and the surface epithelium of the stomach and duodenum. Transitional Cell Carcinomas are positive and Prostate Cancers are negative. This antibody does not recognize intermediate filament proteins, nor does it recognize non-epithelial tissues such as blood vessels, connective tissue, etc.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3669,3.0 mL,Predilute","offer_id":49735814185200,"sku":"BSB 3669","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3670,7.0 mL,Predilute","offer_id":49735814217968,"sku":"BSB 3670","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3671,15.0 mL,Predilute","offer_id":49735814250736,"sku":"BSB 3671","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3671.jpg?v=1778849023"},{"product_id":"pi3692","title":"TintoFast EMA","description":"\u003cp\u003eEpithelial membrane antigen (EMA) is a mucin-like glycoprotein that provides barrier function. According to literature, EMA antibody is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in the bone marrow or liver. It stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3692-3,3.0 mL,Predilute","offer_id":49735814316272,"sku":"BSB-3692-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3692-7,7.0 mL,Predilute","offer_id":49735814349040,"sku":"BSB-3692-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3692-15,15.0 mL,Predilute","offer_id":49735814381808,"sku":"BSB-3692-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3692.jpg?v=1778849068"},{"product_id":"pi3693","title":"TintoFast HMB-45","description":"\u003cp\u003eMalanosome HMB45 antibody reacts against premelanosome protein gp100 present in immature melanosomes, cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. gp100 is a 100 kD membrane bound glycoprotein present in stage I premelanosome, stage II and nonmelanized stage III melanosomes but absent in stage IV melanosomes and melanosomes in keratinocytes. This antibody was generated from an extract of melanoma. It reacted positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, this antibody reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3693-3,3.0 mL,Predilute","offer_id":49735814447344,"sku":"BSB-3693-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3693-7,7.0 mL,Predilute","offer_id":49735814480112,"sku":"BSB-3693-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3693-15,15.0 mL,Predilute","offer_id":49735814512880,"sku":"BSB-3693-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3693.jpg?v=1778849157"},{"product_id":"pi3771","title":"TintoFast Ki-67","description":"\u003cp\u003eThe Ki-67 protein is a cellular marker for proliferation. It is strictly associated with cell proliferation. During the interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. Ki-67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0).\u003c\/p\u003e\n\n\u003cp\u003eKi-67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. The best-studied examples in this context are carcinomas of the prostate and the breast.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3771-3,3.0 mL,Predilute","offer_id":49735814545648,"sku":"BSB-3771-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3771-7,7.0 mL,Predilute","offer_id":49735814578416,"sku":"BSB-3771-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3771-15,15.0 mL,Predilute","offer_id":49735814611184,"sku":"BSB-3771-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3771.jpg?v=1778849215"},{"product_id":"pi3695","title":"TintoFast Melanoma Cocktail: HMB-45, Mart-1 and Tyrosinase","description":"\u003cp\u003eHMB-45 reacts against an antigen present in immature melanosomes, cutaneous, melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. This antibody is very useful to identify Malignant Melanoma. MART-1\/ Melan-A is a protein antigen found on melanocytes. Antibodies against this antigen are used to recognize cells of melanocytic differentiation, useful for the diagnosis of Melanoma. The same name is used to refer to the gene which codes for this antigen. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation.\u003c\/p\u003e\n\n\u003cp\u003eThe MART-1\/Melan-A antigen is specific for the melanocyte lineage found in normal skin, retina, and melanocytes, but not in other normal tissues. It is thus useful as a marker for Melanocytic Tumors, with the caveat that it is normally found in benign nevi as well. Anti-Tyrosinase has been found to be quite specific for melanocytic lesions such as Malignant Melanoma and Melanotic Neurofibroma. Essentially no carcinomas express this marker. Melanoma cocktail HMB-45, Mart-1 and Tyrosinase are ideally suited to detect melanomas and melanocytic lesions and may prove to be a valuable marker for melanoma metastasis in sentinel lymph nodes.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3695-3,3.0 mL,Predilute","offer_id":49735814676720,"sku":"BSB-3695-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3695-7,7.0 mL,Predilute","offer_id":49735814709488,"sku":"BSB-3695-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3695-15,15.0 mL,Predilute","offer_id":49735814742256,"sku":"BSB-3695-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3695.jpg?v=1778849256"},{"product_id":"pi3696","title":"TintoFast NGFR","description":"\u003cp\u003eNGFR (Nerve Growth Factor Receptor), also termed p75 or CD271, is the low-affinity NGFR (LNGFR) which binds NGF and other neurotrophins, including BDNF, NT3 and NT4\/5 with similar low-affinity. NGFR p75 is a 75 kD transmembrane glycoprotein that is mainly expressed in Schwann cells and neurons and in a variety of non-neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase\/ceramide pathway, the ICE-like proteases and the JNK pathway. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3696-3,3.0 mL,Predilute","offer_id":49735814775024,"sku":"BSB-3696-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3696-7,7.0 mL,Predilute","offer_id":49735814807792,"sku":"BSB-3696-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3696-15,15.0 mL,Predilute","offer_id":49735814840560,"sku":"BSB-3696-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3696.jpg?v=1778849527"},{"product_id":"pi3697","title":"TintoFast p40","description":"\u003cp\u003eΔNp63 (also known as p40) is an isoform of p63, a transcription factor that belongs to the p53 family of proteins involved in the regulation of cell proliferation, differentiation, and apoptosis. p63 is essential for the development and maintenance of epithelial cell growth and stratification in tissues such as the skin, oral cavity, mammary gland, prostate, and urogenital tract, where it regulates the expression of genes involved in epithelial during embryonic development and tissue homeostasis.\u003c\/p\u003e\n\n\u003cp\u003eAlternative usage of different promoters of TP63 gene results in two major isoforms, TAp63 and NH2-terminal truncated ΔNp63, which lacks the canonical transactivating domain (TA1). All p63 isoforms contain a central DNA-binding domain (DBD) and an oligomerization domain (OD). anti-p40 recognizes ΔNp63 isoform and it is highly specific for squamous\/basal cells. p40 signal is typically strong and diffuse in squamous cell carcinoma (SCC), distinguishing squamous cell-derived tumors from other types of carcinoma.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3697-3,3.0 mL,Predilute","offer_id":49735814906096,"sku":"BSB-3697-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3697-7,7.0 mL,Predilute","offer_id":49735814938864,"sku":"BSB-3697-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3697-15,15.0 mL,Predilute","offer_id":49735814971632,"sku":"BSB-3697-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3697.jpg?v=1778857444"},{"product_id":"pi3698","title":"TintoFast p63","description":"\u003cp\u003eIn addition to p53, mammalian cells contain two homologous genes, p63 and p73. These genes give rise to the expression of proteins that are highly similar to p53 in structure and function. In particular, p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development.\u003c\/p\u003e\n\n\u003cp\u003eAnti-p63 to human p63 protein labels an epitope common to all six p63 isotypes (TAp63α, TAp63β, TAp63γ, ΔNp63α, ΔNp63β, ΔNp63γ). p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3698-3,3.0 mL,Predilute","offer_id":49735815037168,"sku":"BSB-3698-3","price":400.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3698-7,7.0 mL,Predilute","offer_id":49735815069936,"sku":"BSB-3698-7","price":734.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3698-15,15.0 mL,Predilute","offer_id":49735815102704,"sku":"BSB-3698-15","price":1267.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/p63-RMab-20X-1KID03-10-1-BCC-300x230.jpg?v=1787360212"},{"product_id":"pi3699","title":"TintoFast Podoplanin","description":"\u003cp\u003ePodoplanin, also known as D2-40, is a mucin-type transmembrane glycoprotein involved in a wide variety of functions including regulation of organ development, cell motility, tumorigenesis and metastasis. Expression patterns have been seen in different organs including the central nervous system, kidney, lung, heart, intestine, and lymphoid organs. It is predominantly expressed in lymphatic endothelial cells, where it contributes to the maintenance of lymphatic vessel integrity, lymphangiogenesis, and lymphatic fluid drainage. Podoplanin interacts with other proteins, such as CLEC-2, and mediates signaling pathways involved in lymphatic development and function. Podoplanin expression is often upregulated in tumors, particularly those with a propensity for lymphatic metastasis where it promotes tumor lymphangiogenesis by inducing the proliferation and migration of lymphatic endothelial cells, thereby facilitating the spread of cancer cells to regional lymph nodes and distant organs. Podoplanin expression has been reported in various types of cancer, including squamous cell carcinoma, malignant mesothelioma, germ cell tumors, and certain types of sarcoma.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3699-3,3.0 mL,Predilute","offer_id":49735815135472,"sku":"BSB-3699-3","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3699-7,7.0 mL,Predilute","offer_id":49735815168240,"sku":"BSB-3699-7","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3699-15,15.0 mL,Predilute","offer_id":49735815201008,"sku":"BSB-3699-15","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3699.jpg?v=1778857533"},{"product_id":"pi3774","title":"TintoFast Prame","description":"\u003cp\u003eMelanoma antigen preferentially expressed in tumors is a protein that in humans is encoded by the PRAME gene. This gene encodes an antigen that is predominantly expressed in human Melanomas and is recognized by cytolytic T lymphocytes. PRAME is not expressed in normal tissues, except in testis. This expression pattern is like that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this antigen is also expressed in Acute Leukemias.\u003c\/p\u003e\n\n\u003cp\u003ePRAME overexpression in triple negative breast cancer has also been found to promote cancer cell motility through induction of the epithelial-to-mesenchymal transition. PRAME mRNA expression is well documented in Cutaneous and Ocular Melanomas. One study concluded that diffuse nuclear immunoreactivity for PRAME was found in 87% of metastatic and 83.2% of primary Melanomas. Among Melanoma subtypes, PRAME was diffusely expressed in 94.4% of acral Melanomas, 92.5% of superficial spreading Melanomas, 90% of Nodular Melanomas, 88.6% of Lentigo Maligna Melanomas, and 35% of Desmoplastic Melanomas. When in situ and NonDesmoplastic Invasive Melanoma components were present, PRAME expression was seen in both. Most Melanocytic nevi (86.4%), were completely negative for PRAME.\u003c\/p\u003e\n\n\u003cp\u003eImmunoreactivity for PRAME was seen, albeit usually only in a minor subpopulation of lesional Melanocytes, in 13.6% of Cutaneous Nevi, including Dysplastic Nevi, Common Acquired Nevi, Traumatized\/recurrent Nevi, and Spitz Nevi. Rare isolated junctional Melanocytes with immunoreactivity for PRAME were also seen in Solar Lentigines and benign nonlesional skin. This study suggests that immunohistochemical analysis for PRAME expression may be useful for diagnostic purposes to support a suspected diagnosis of Melanoma. It may also be valuable for margin assessment of a known PRAME-positive Melanoma, but its expression in Nevi, Solar Lentigines, and Benign nonlesional Skin can represent a challenge.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3774-3,3.0 mL,Predilute","offer_id":49735815233776,"sku":"BSB-3774-3","price":400.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3774-7,7.0 mL,Predilute","offer_id":49735815266544,"sku":"BSB-3774-7","price":734.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3774-15,15.0 mL,Predilute","offer_id":49735815299312,"sku":"BSB-3774-15","price":1267.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3774.jpg?v=1778857581"},{"product_id":"pi3683","title":"TintoFast CD34","description":"\u003cp\u003eCD34 functions as a cell-cell adhesion factor and cell-surface glycoprotein. It may also mediate the attachment of stem cells to bone marrow extracellular matrixes or directly to stromal cells. Cells expressing CD34 are normally found in the umbilical cord and bone marrow as hematopoietic cells, and in vascular endothelium. In addition to stem cell recognition, CD34 is expressed by vascular endothelium; it appears that proliferating endothelial cells express this molecule in greater amounts than resting cells. In comparison to factor VIII R Antigen, CD34 stains are stronger and appear to be more sensitive in nature. In tumors, CD34 is found in Alveolar Soft Part Sarcoma, pre B-ALL (positive in 75%), AML(40%), AMLM7 (most), Dermatofibrosarcoma Protuberans, Gastrointestinal Stromal Tumors, Giant Cell Fibroblastoma, Granulocytic Sarcoma, Kaposi’s Sarcoma, Liposarcoma, Malignant Fibrous Histiocytoma, Malignant Peripheral Nerve Sheath tumors, Meningeal Hemangiopericytomas, Meningiomas, Neurofibromas, Schwannomas, and Papillary Thyroid Carcinoma. A negative CD34 may exclude Ewing’s Sarcoma\/PNET, Myofibrosarcoma of the breast, and Inflammatory Myofibroblastic tumors of the stomach.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3681,3.0 mL,Predilute","offer_id":50087266484464,"sku":"BSB 3681","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3682,7.0 mL,Predilute","offer_id":50087266517232,"sku":"BSB 3682","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3683,15.0 mL,Predilute","offer_id":50087266550000,"sku":"BSB 3683","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/TintoFastCD34.png?v=1786489073"},{"product_id":"pi3668","title":"TintoFast CK 5 and 6","description":"\u003cp\u003eCytokeratin 5 (58 kDa) is a high-molecular weight, basic type of cytokeratin expressed in basal, intermediate and superficial-cell layers of stratified epithelia as well as transitional epithelia, complex epithelia, mesothelial cells and Mesothelioma. Cytokeratin 6 (56 kD) is also a high-molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3666,3.0 mL,Predilute","offer_id":50087266582768,"sku":"BSB 3666","price":400.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3667,7.0 mL,Predilute","offer_id":50087266615536,"sku":"BSB 3667","price":734.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3668,15.0 mL,Predilute","offer_id":50087266648304,"sku":"BSB 3668","price":1267.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/TintoFastCK5and6.png?v=1786489155"},{"product_id":"pi3665","title":"TintoFast CK AE1 and AE3","description":"\u003cp\u003eCytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: the low-weight, acidic Type I cytokeratins and the high-weight, basic or neutral Type II cytokeratins. Cytokeratins are usually found in pairs comprising a Type I cytokeratin and a Type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue-specific. Cytokeratin cocktail AE1\/AE3 is well suited to distinguish Epithelial Carcinoma from Non-epithelial malignancies and is used to aid Epithelial Tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin-containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues. This antibody has shown high sensitivity and specificity in recognizing epithelial cells of neoplastic origin.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3663,3.0 mL,Predilute","offer_id":50087266681072,"sku":"BSB 3663","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3664,7.0 mL,Predilute","offer_id":50087266713840,"sku":"BSB 3664","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3665,15.0 mL,Predilute","offer_id":50087266746608,"sku":"BSB 3665","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/TintoFastCDAE1andAE3.png?v=1786489225"},{"product_id":"pi3680","title":"TintoFast EpCAM","description":"\u003cp\u003eEpithelial Cell Adhesion Molecule (EpCAM) or Epithelial Specific Antigen is a 40kD cell surface antigen that is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. These glycoproteins are located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells, with the exception of most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. However, focal positivity may be seen in the basal layer of squamous cell epithelium of endoderm (e.g., palatine tonsils) and mesoderm (e.g., uterine cervix). EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumor cells, and de novo expression being seen in dysplastic squamous epithelium. Epithelial specific antigen has been known to play an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma. EpCAM can be used to distinguish among Basal Cell, Basosquamous Carcinomas and Squamous Cell Carcinomas of the skin.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3678,3.0 mL,Predilute","offer_id":50087266844912,"sku":"BSB 3678","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3679,7.0 mL,Predilute","offer_id":50087266877680,"sku":"BSB 3679","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3680,15.0 mL,Predilute","offer_id":50087266910448,"sku":"BSB 3680","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/TintoFastEpCAM.png?v=1786489684"},{"product_id":"pi3653","title":"TintoFast MART-1","description":"\u003cp\u003eMART-1\/Melan-A is a putative 18 kDa transmembrane protein consisting of 118 amino acids. It has a single transmembrane domain. MART-1\/ Melan-A is a protein antigen found on melanocytes. Antibodies against this antigen are used to recognize cells of melanocytic differentiation, useful for the diagnosis of Melanoma. The same name is used to refer to the gene which codes for this antigen. The MART-1\/Melan-A antigen is specific for the melanocyte lineage found in normal skin, retina, and melanocytes, but not in other normal tissues. It is thus useful as a marker for Melanocytic Tumors, with the caveat that it is normally found in benign nevi as well. This antibody is very useful in establishing the diagnosis of Metastatic Melanomas.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3651,3.0 mL,Predilute","offer_id":50087266943216,"sku":"BSB 3651","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3652,7.0 mL,Predilute","offer_id":50087266975984,"sku":"BSB 3652","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3653,15.0 mL,Predilute","offer_id":50087267008752,"sku":"BSB 3653","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/TintoFastMART-1.png?v=1786489622"},{"product_id":"pi3659","title":"TintoFast MiTF","description":"\u003cp\u003eMicrophthalmia-associated Transcription Factor (MiTF) is a basic helix-loop-helix leucine zipper transcription factor involved in melanocyte and osteoclast development. Mutations in MiTF cause auditory pigmentary syndromes, such as Waardenburg Syndrome Type II, Type IIa and Tietz Syndrome in humans. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 Melonoma cells (but not other Melanoma cell lines), as well as mast cells and heart cells. MiTF plays a critical role in the differentiation of various cell types such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. This antibody recognizes serine phosphorylated and non-phosphorylated melanocytic isoforms of microphthalmia. It is useful in identifying Malignant Melanoma, and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3657,3.0 mL,Predilute","offer_id":50087267041520,"sku":"BSB 3657","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3658,7.0 mL,Predilute","offer_id":50087267074288,"sku":"BSB 3658","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3659,15.0 mL,Predilute","offer_id":50087267107056,"sku":"BSB 3659","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/TintoFastMiTF_970840e2-9a75-4aeb-bfe9-981d0df51d47.png?v=1786489573"},{"product_id":"pi3656","title":"TintoFast SOX-10","description":"\u003cp\u003eTranscription factor SOX-10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been recently shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. SOX-10 is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells which usually express S100 protein. In scar specimens, immature fibroblasts, epithelioid granulomas, and histiocytic proliferations can histopathologically mimic residual melanoma and even be positive for MiTF and S100. However, SOX-10 is less likely to be expressed by fibroblasts or histiocytes, especially compared to MiTF and S100. Anti-SOX-10 produces a nuclear stain that provides a clean signal that is much sharper and darker in staining quality when compared to the use of antibodies against MiTF and S100.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3654,3.0 mL,Predilute","offer_id":50087267172592,"sku":"BSB 3654","price":382.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3655,7.0 mL,Predilute","offer_id":50087267205360,"sku":"BSB 3655","price":700.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3656,15.0 mL,Predilute","offer_id":50087267238128,"sku":"BSB 3656","price":1210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/ScreenShot2026-07-28at2.16.02AM.png?v=1785230168"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/collections\/Group_1686567559_converted.webp?v=1764848062","url":"https:\/\/www.biosb.com\/collections\/fast-mohs-ihc.oembed?page=2","provider":"Biosb","version":"1.0","type":"link"}