{"title":"Indirect Immunofluorescence","description":"","products":[{"product_id":"pi3017","title":"Albumin","description":"\u003cp\u003eThe albumins are a family of globular proteins, the most common of which are the serum albumins. Albumins are commonly found in blood plasma and differ from other blood proteins in that they are not glycosylated. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in this gene on chromosome 4 result in various anomalous proteins.\n\u003cbr\u003e \n\u003cbr\u003e Low albumin (hypoalbuminemia) may be caused by liver disease, nephrotic syndrome, burns, protein-losing enteropathy, malabsorption, malnutrition, late pregnancy, artefact, genetic variations and malignancy. High albumin (hyperalbuminemia) is almost always caused by dehydration. In some cases of retinol (Vitamin A) deficiency, the albumin level can be elevated to high-normal values.\n\u003cbr\u003e \n\u003cbr\u003e In systemic lupus erythematosus (SLE) patients, reports have been published of an increased prevalence of IgG autoantibodies against human serum albumin (anti-HSA IgG) that are associated with SLE disease activity.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3012,3.0 mL,Tinto Predilute","offer_id":49735302414576,"sku":"BSB 3012","price":174.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3013,7.0 mL,Tinto Predilute","offer_id":49735302447344,"sku":"BSB 3013","price":319.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3014,15.0 mL,Tinto Predilute","offer_id":49735302480112,"sku":"BSB 3014","price":572.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3015,,Concentrate","offer_id":49735302512880,"sku":"BSB 3015","price":159.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3016,,Concentrate","offer_id":49735302545648,"sku":"BSB 3016","price":316.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3017,,Concentrate","offer_id":49735302578416,"sku":"BSB 3017","price":628.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3017.jpg?v=1778681995"},{"product_id":"pi2808","title":"Amyloid A","description":"\u003cp\u003eSerum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs). These proteins are produced predominantly by the liver. The conservation of these proteins throughout invertebrates and vertebrates suggests that SAAs play a highly essential role in all animals. Acute-phase serum amyloid A proteins (A-SAAs) are secreted during the acute phase of inflammation. These proteins have several roles, including the transport of cholesterol to the liver for secretion into the bile, the recruitment of immune cells to inflammatory sites, and the induction of enzymes that degrade extracellular matrix. A-SAAs are implicated in several chronic inflammatory diseases, such as amyloidosis, atherosclerosis, and rheumatoid arthritis.\n\u003cbr\u003e \n\u003cbr\u003e Amyloidosis is a disease characterized by the abnormal build-up of amyloid, abnormal non-branching fibrillary β-pleated sheet proteins that are insoluble and highly resistant to proteolytic degradation that result in localized or systemic organ dysfunction. Amyloidosis are grouped as AL (primary), AA (secondary), and hereditary forms. Proper classification is important since treatment and prognosis of the disorders are vastly different. AA amyloidosis is associated with a variety of chronic inflammatory conditions and infections, derived from SAA. Immunohistochemical staining using a panel of antibodies including κ and λ Ig light chains, Amyloid A, and Transthyretin can aid in recognizing most forms of amyloid. The Amyloid A immunostaining detects tissue deposition of serum Amyloid A protein, an acute phase reactive protein. It is positive in AA Amyloidosis and familial Mediterranean fever. Recently, SAA has also been investigated as a potential marker for neoplastic activity. SAA concentrations have been reported to be a marker of poor prognosis, elevated in patients with advanced stages of cancer and those with malignant disease.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 2803,3.0 mL,Tinto Predilute","offer_id":49735307165936,"sku":"BSB 2803","price":225.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2804,7.0 mL,Tinto Predilute","offer_id":49735307198704,"sku":"BSB 2804","price":375.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2805,15.0 mL,Tinto Predilute","offer_id":49735307231472,"sku":"BSB 2805","price":753.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2806,0.1 mL,Concentrate","offer_id":49735307264240,"sku":"BSB 2806","price":195.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2807,0.5 mL,Concentrate","offer_id":49735307297008,"sku":"BSB 2807","price":595.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2808,1.0 mL,Concentrate","offer_id":49735307329776,"sku":"BSB 2808","price":1121.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI2808.jpg?v=1778682892"},{"product_id":"pi3024","title":"C1q","description":"\u003cp\u003eThe complement component 1q (C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the C1 complex. Antibodies of the adaptive immune system can bind antigen, forming an antigen-antibody complex. When C1q binds antigen-antibody complexes, the C1 complex becomes activated. Activation of the C1 complex initiates the classical complement pathway of the complement system.\n\u003cbr\u003e \n\u003cbr\u003e C1q nephropathy is a rare glomerular disease with characteristic mesangial C1q deposition noted on IHC or IF microscopy. It is histologically defined and poorly understood. Light microscopic features are heterogeneous and comprise minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and proliferative glomerulonephritis. Clinical presentation is also diverse, and ranges from asymptomatic hematuria or proteinuria to frank nephritic or nephrotic syndrome in both children and adults. Hypertension and renal insufficiency at the time of diagnosis are common findings. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3019,3.0 mL,Tinto Predilute","offer_id":49735324270832,"sku":"BSB 3019","price":289.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3020,7.0 mL,Tinto Predilute","offer_id":49735324303600,"sku":"BSB 3020","price":522.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3021,15.0 mL,Tinto Predilute","offer_id":49735324336368,"sku":"BSB 3021","price":941.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3022,0.1 mL,Concentrate","offer_id":49735324369136,"sku":"BSB 3022","price":183.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3023,0.5 mL,Concentrate","offer_id":49735324401904,"sku":"BSB 3023","price":445.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3024,1.0 mL,Concentrate","offer_id":49735324434672,"sku":"BSB 3024","price":867.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3024.jpg?v=1778685348"},{"product_id":"pi3031","title":"C3c","description":"\u003cp\u003eComplement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity.\n\u003cbr\u003e \n\u003cbr\u003e C3 glomerulopathy was recently coined to describe renal biopsy appearances characterized by the presence of glomerular deposits composed predominantly of C3 in the absence of significant amounts of Ig. The presence of C3 in the absence of Ig suggests activation of complement by antibody-independent pathways, typically the alternative pathway, and many patients with this type of renal lesion have evidence of genetic or acquired alternative pathway dysregulation. C3 glomerulopathy has been further divided into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) based on electron microscopy (EM) appearances. The underlying genetic defect has been identified in some hereditary forms of C3GN such as CFHR5 nephropathy. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3026,3.0 mL,Tinto Predilute","offer_id":49735324631280,"sku":"BSB 3026","price":275.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3027,7.0 mL,Tinto Predilute","offer_id":49735324664048,"sku":"BSB 3027","price":499.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3028,15.0 mL,Tinto Predilute","offer_id":49735324696816,"sku":"BSB 3028","price":898.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3029,0.1 mL,Concentrate","offer_id":49735324729584,"sku":"BSB 3029","price":167.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3030,0.5 mL,Concentrate","offer_id":49735324762352,"sku":"BSB 3030","price":409.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3031,1.0 mL,Concentrate","offer_id":49735324795120,"sku":"BSB 3031","price":796.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3031.jpg?v=1778740789"},{"product_id":"pi6392","title":"C3d","description":"\u003cp\u003eComplement component 3, or C3, is a protein of the immune system that plays a central role in the complement system and contributes to innate immunity. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss.\n\u003cbr\u003e \n\u003cbr\u003e Anti-C3d combined with anti-C4d can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. C3d is also a helpful adjunct in the diagnosis of bullous pemphigoid (BP) and perhaps pemphigus vulgaris (PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 6387,3.0 mL,Tinto Predilute","offer_id":49735325024496,"sku":"BSB 6387","price":275.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6388,7.0 mL,Tinto Predilute","offer_id":49735325057264,"sku":"BSB 6388","price":499.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6389,15.0 mL,Tinto Predilute","offer_id":49735325090032,"sku":"BSB 6389","price":898.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6390,0.1 mL,Concentrate","offer_id":49735325122800,"sku":"BSB 6390","price":167.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6391,0.5 mL,Concentrate","offer_id":49735325155568,"sku":"BSB 6391","price":409.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6392,1.0 mL,Concentrate","offer_id":49735325188336,"sku":"BSB 6392","price":796.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI6392.jpg?v=1778740913"},{"product_id":"pi3038","title":"C4c","description":"\u003cp\u003eComplement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen(HLA) system. It serves several critical functions in immunity, tolerance, and autoimmunity with the other numerous components.\n\u003cbr\u003e \n\u003cbr\u003e Low serum complement activity or low protein concentrations of complement C4 are found on Systemic Lupus Erythematosus (SLE) and it is often associated with Congenital C4 deficiency. Complete deficiencies of complement components are among the strongest genetic risk factors for SLE or lupus-like disease, across HLA haplotypes and racial backgrounds.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3033,3.0 mL,Predilute","offer_id":49735325253872,"sku":"BSB 3033","price":275.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3034,7.0 mL,Predilute","offer_id":49735325286640,"sku":"BSB 3034","price":499.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3035,15.0 mL,Predilute","offer_id":49735325319408,"sku":"BSB 3035","price":898.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3036,0.1 mL,Concentrate","offer_id":49735325352176,"sku":"BSB 3036","price":167.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3037,0.5 mL,Concentrate","offer_id":49735325384944,"sku":"BSB 3037","price":409.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3038,1.0 mL,Concentrate","offer_id":49735325417712,"sku":"BSB 3038","price":796.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3038.jpg?v=1778740964"},{"product_id":"pi2836","title":"C4d","description":"\u003cp\u003eComplement component 4, or C4, plays a central role in the complement system. C4d is the final proteolytic remnant of deposited C4b on endothelium and remains covalently attached to endothelium for little more than a week. It is easily detectable by Immunohistochemistry.\n\u003cbr\u003e Anti-C4d combined with anti-C3d can be utilized as a tool for diagnosis of AR (Acute Rejection) and warrant prompt and aggressive anti-rejection treatment. C4d can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 2831,3.0 mL,Predilute","offer_id":49735326466288,"sku":"BSB 2831","price":314.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2832,7.0 mL,Predilute","offer_id":49735326499056,"sku":"BSB 2832","price":569.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2833,15.0 mL,Predilute","offer_id":49735326531824,"sku":"BSB 2833","price":1028.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2834,0.1 mL,Concentrate","offer_id":49735326564592,"sku":"BSB 2834","price":186.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2835,0.5 mL,Concentrate","offer_id":49735326597360,"sku":"BSB 2835","price":521.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2836,1.0 mL,Concentrate","offer_id":49735326630128,"sku":"BSB 2836","price":975.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI2836.jpg?v=1778741148"},{"product_id":"pi3052","title":"Fibrinogen","description":"\u003cp\u003eFibrinogen (factor I) is a glycoprotein that circulates in the blood of vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and subsequently to a fibrin-based blood clot. Fibrinogen functions primarily to occlude blood vessels and thereby stop excessive bleeding. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby functions to promote tissue revascularization, wound healing, and tissue repair.\n\u003cbr\u003e \n\u003cbr\u003e Several disorders (Congenital afibrinogenemia, hypofibrinogenemia, Fibrinogen storage disease, Hereditary fibrinogen Aα-Chain amyloidosis, Congenital hypodysfibrinogenemia, Cryofibrinogenemia, acquired hypofibrinogenemia, Chronic Kidney Disease, etc.) in the quantity and\/or quality of fibrinogen cause pathological bleeding, pathological blood clotting, and\/or the deposition of fibrinogen in the liver, kidneys, and other tissues. Chronic kidney disease (CKD) patients have increased rates of bleeding as well as thrombosis. Fibrinogen and platelets combine to generate a mature clot, but in CKD platelets are dysfunctional.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3047,3.0 mL,Predilute","offer_id":49735410352368,"sku":"BSB 3047","price":183.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3048,7.0 mL,Predilute","offer_id":49735410385136,"sku":"BSB 3048","price":335.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3049,15.0 mL,Predilute","offer_id":49735410417904,"sku":"BSB 3049","price":601.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3050,0.1 mL,Concentrate","offer_id":49735410450672,"sku":"BSB 3050","price":167.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3051,0.5 mL,Concentrate","offer_id":49735410483440,"sku":"BSB 3051","price":330.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3052,1.0 mL,Concentrate","offer_id":49735410516208,"sku":"BSB 3052","price":658.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3052.jpg?v=1778762162"},{"product_id":"pi3777","title":"Collagen Type IV","description":"\u003cp\u003eCollagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the total protein content. Collagen IV is a major constituent of the basement membranes, along with laminins and enactins. It is composed of the alpha 1 IV chain and alpha 2 IV chain in a 2:1 ratio. It can form insoluble fibers with high tensile strength. \n\u003cbr\u003e \n\u003cbr\u003e Normal tissue stains with this antibody in a manner consistent with the sites of mesenchymal elements and epithelial basal laminae. Antibody to collagen IV is useful in detecting the loss of parts of the basement membrane in carcinomas. Collagen IV can also be useful in the classification of soft tissue tumors; Schwanomas, Leiomyomas, and their well-differentiated malignant counterparts usually immune react to this antibody. The vascular nature of neoplasms, Hemangiopericytoma, Angiosarcoma and Epithelioid Hemangioendothelioma can be observed with this antibody.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB-3777-3,3.0 mL,Tinto Predilute","offer_id":49735523696880,"sku":"BSB-3777-3","price":250.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3777-7,7.0 mL,Tinto Predilute","offer_id":49735523729648,"sku":"BSB-3777-7","price":445.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3777-15,15.0 mL,Tinto Predilute","offer_id":49735523762416,"sku":"BSB-3777-15","price":784.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3777-01,0.1 mL,Concentrate","offer_id":49735523795184,"sku":"BSB-3777-01","price":258.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3777-05,0.5 mL,Concentrate","offer_id":49735523827952,"sku":"BSB-3777-05","price":561.0,"currency_code":"USD","in_stock":true},{"title":"BSB-3777-1,1.0 mL,Concentrate","offer_id":49735523860720,"sku":"BSB-3777-1","price":893.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3777.jpg?v=1778765753"},{"product_id":"pi5356","title":"Collagen Type IV","description":"\u003cp\u003eCollagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the total protein content. Collagen IV is a major constituent of the basement membranes, along with laminins and enactins. It is composed of the alpha 1 IV chain and alpha 2 IV chain in a 2:1 ratio. It can form insoluble fibers with high tensile strength.\n\u003cbr\u003e \n\u003cbr\u003e Normal tissue stains with this antibody in a manner consistent with the sites of mesenchymal elements and epithelial basal laminae. Antibody to collagen IV is useful in detecting the loss of parts of the basement membrane in carcinomas. Collagen IV can also be useful in the classification of soft tissue tumors; Schwannomas, Leiomyomas, and their well-differentiated malignant counterparts usually immunoreact to this antibody. The vascular nature of neoplasms, Hemangiopericytoma, Angiosarcoma and Epithelioid Hemangioendothelioma can be observed with this antibody.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5351,3.0 mL,Predilute","offer_id":49735523926256,"sku":"BSB 5351","price":179.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5352,7.0 mL,Predilute","offer_id":49735523959024,"sku":"BSB 5352","price":323.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5353,15.0 mL,Predilute","offer_id":49735523991792,"sku":"BSB 5353","price":577.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5354,0.1 mL,Concentrate","offer_id":49735524024560,"sku":"BSB 5354","price":156.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5355,0.5 mL,Concentrate","offer_id":49735524057328,"sku":"BSB 5355","price":332.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5356,1.0 mL,Concentrate","offer_id":49735524090096,"sku":"BSB 5356","price":578.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5356.jpg?v=1778765697"},{"product_id":"pi3059","title":"IgA","description":"\u003cp\u003eImmunoglobulin A (IgA) is the main immunoglobulin in mucous secretions, including tears, saliva, and colostrum, as well as respiratory, intestinal, prostatic, and vaginal secretions. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA provides protection against microbes proliferating in body secretions, especially those of the digestive and respiratory tracts.\n\u003cbr\u003e \n\u003cbr\u003e IgA antibody reacts with surface immunoglobulin IgA alpha chains. It is extremely useful when identifying Acute Leukemias, IgA Myelomas, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. However, due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3054,3.0 mL,Predilute","offer_id":49735555743984,"sku":"BSB 3054","price":97.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3055,7.0 mL,Predilute","offer_id":49735555776752,"sku":"BSB 3055","price":158.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3056,15.0 mL,Predilute","offer_id":49735555809520,"sku":"BSB 3056","price":287.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3057,0.1 mL,Concentrate","offer_id":49735555842288,"sku":"BSB 3057","price":124.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3058,0.5 mL,Concentrate","offer_id":49735555875056,"sku":"BSB 3058","price":158.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3059,1.0 mL,Concentrate","offer_id":49735555907824,"sku":"BSB 3059","price":223.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3059.jpg?v=1778772613"},{"product_id":"pi5664","title":"IgA","description":"\u003cp\u003eImmunoglobulin A (IgA) is the main immunoglobulin in mucous secretions, including tears, saliva, and colostrum, as well as respiratory, intestinal, prostatic, and vaginal secretions. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA provides protection against microbes proliferating in body secretions, especially those of the digestive and respiratory tracts.\n\u003cbr\u003e \n\u003cbr\u003e IgA antibody reacts with surface immunoglobulin IgA alpha chains. It is extremely useful when identifying Acute Leukemias, IgA Myelomas, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. However, due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5659,3.0 mL,Tinto Predilute","offer_id":49735556628720,"sku":"BSB 5659","price":103.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5660,7.0 mL,Tinto Predilute","offer_id":49735556661488,"sku":"BSB 5660","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5661,15.0 mL,Tinto Predilute","offer_id":49735556694256,"sku":"BSB 5661","price":299.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5662,0.1 mL,Concentrate","offer_id":49735556727024,"sku":"BSB 5662","price":130.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5663,0.5 mL,Concentrate","offer_id":49735556759792,"sku":"BSB 5663","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5664,1.0 mL,Concentrate","offer_id":49735556792560,"sku":"BSB 5664","price":233.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5664.jpg?v=1778772659"},{"product_id":"pi2962","title":"IgD","description":"\u003cp\u003eIgD makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes (coexpressed with IgM) and is also found in serum in very small amounts. It is monomeric and incorporates the alpha-heavy chain in its structure. IgD’s function is currently unknown, as mice lacking IgD seem to retain normal immune responses (implying redundancy if not lack of function), and IgD ceases to be expressed in activated B-lymphocytes. It may function as a regulatory antigen receptor. IgD antibody reacts with surface immunoglobulin IgD delta chains. This antibody is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived from Lymphomas, specifically Marginal Zone Lymphoma.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 2957,3.0 mL,Tinto Predilute","offer_id":49735557939440,"sku":"BSB 2957","price":179.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2958,7.0 mL,Tinto Predilute","offer_id":49735557972208,"sku":"BSB 2958","price":326.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2959,15.0 mL,Tinto Predilute","offer_id":49735558004976,"sku":"BSB 2959","price":586.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2960,0.1 mL,Concentrate","offer_id":49735558037744,"sku":"BSB 2960","price":183.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2961,0.5 mL,Concentrate","offer_id":49735558070512,"sku":"BSB 2961","price":361.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2962,1.0 mL,Concentrate","offer_id":49735558103280,"sku":"BSB 2962","price":668.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI2962.jpg?v=1778772749"},{"product_id":"pi3072","title":"IgE","description":"\u003cp\u003eIgE, Immunoglobulin E, is an isotype of antibody only found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgE's main function is immunity to parasites such as helminths like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica. IgE is utilized during immune defense against certain protozoan parasites such as Plasmodium falciparum.\n\u003cbr\u003e \n\u003cbr\u003e IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis. IgE also plays a pivotal role in responses to allergens, such as: anaphylactic drugs, bee stings, and antigen preparations used in desensitization immunotherapy. IgE is known to be elevated in various autoimmune disorders such as Lupus(SLE), Rheumatoid Arthritis(RA) \u0026amp; psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3067,3.0 mL,Predilute","offer_id":49735558955248,"sku":"BSB 3067","price":174.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3068,7.0 mL,Predilute","offer_id":49735558988016,"sku":"BSB 3068","price":319.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3069,15.0 mL,Predilute","offer_id":49735559020784,"sku":"BSB 3069","price":572.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3070,0.1 mL,Concentrate","offer_id":49735559053552,"sku":"BSB 3070","price":159.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3071,0.5 mL,Concentrate","offer_id":49735559086320,"sku":"BSB 3071","price":316.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3072,1.0 mL,Concentrate","offer_id":49735559119088,"sku":"BSB 3072","price":628.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3072.jpg?v=1778772830"},{"product_id":"pi5678","title":"IgG","description":"\u003cp\u003eIgG is a monomeric immunoglobulin, composed of two heavy chains and two light chains. This is the most abundant immunoglobulin and is approximately equally distributed in blood and tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the placenta and bind to many kinds of pathogens. IgG protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralization of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%).\n\u003cbr\u003e \n\u003cbr\u003e IgG antibody reacts with surface immunoglobulin IgG gamma chains. This antibody is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5673,3.0 mL,Tinto Predilute","offer_id":49735559708912,"sku":"BSB 5673","price":103.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5674,7.0 mL,Tinto Predilute","offer_id":49735559741680,"sku":"BSB 5674","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5675,15.0 mL,Tinto Predilute","offer_id":49735559774448,"sku":"BSB 5675","price":299.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5676,0.1 mL,Concentrate","offer_id":49735559807216,"sku":"BSB 5676","price":130.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5677,0.5 mL,Concentrate","offer_id":49735559839984,"sku":"BSB 5677","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5678,1.0 mL,Concentrate","offer_id":49735559872752,"sku":"BSB 5678","price":233.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5678.jpg?v=1778772916"},{"product_id":"pi6812","title":"IgG4","description":"\u003cp\u003eIgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma.\n\u003cbr\u003e \n\u003cbr\u003e Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibits significantly more IgG4-positive plasma cells in affected tissues but also significantly higher IgG4\/ IgG ratios (typically \u0026gt; 30%).\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 6807,3.0 mL,Tinto Predilute","offer_id":49735560495344,"sku":"BSB 6807","price":189.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6808,7.0 mL,Tinto Predilute","offer_id":49735560528112,"sku":"BSB 6808","price":342.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6809,15.0 mL,Tinto Predilute","offer_id":49735560560880,"sku":"BSB 6809","price":614.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6810,0.1 mL,Concentrate","offer_id":49735560593648,"sku":"BSB 6810","price":173.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6811,0.5 mL,Concentrate","offer_id":49735560626416,"sku":"BSB 6811","price":427.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6812,1.0 mL,Concentrate","offer_id":49735560659184,"sku":"BSB 6812","price":630.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI6812.jpg?v=1778773001"},{"product_id":"pi6819","title":"IgG4","description":"\u003cp\u003eIgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma.\n\u003cbr\u003e \n\u003cbr\u003e Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibits significantly more IgG4-positive plasma cells in affected tissues but also significantly higher IgG4\/ IgG ratios (typically \u0026gt; 30%).\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 6814,3.0 mL,Tinto Predilute","offer_id":49735560888560,"sku":"BSB 6814","price":220.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6815,7.0 mL,Tinto Predilute","offer_id":49735560921328,"sku":"BSB 6815","price":399.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6816,15.0 mL,Tinto Predilute","offer_id":49735560954096,"sku":"BSB 6816","price":721.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6817,0.1 mL,Concentrate","offer_id":49735560986864,"sku":"BSB 6817","price":245.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6818,0.5 mL,Concentrate","offer_id":49735561019632,"sku":"BSB 6818","price":539.0,"currency_code":"USD","in_stock":true},{"title":"BSB 6819,1.0 mL,Concentrate","offer_id":49735561052400,"sku":"BSB 6819","price":822.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI6819.jpg?v=1778773055"},{"product_id":"pi3085","title":"IgM","description":"\u003cp\u003eIgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer or occasionally as a hexamer. It has a large molecular mass of approximately 900 kDa (in its pentamer form). In germline cells, the gene segment encoding the constant region of the heavy chain is positioned first among other constant region gene segments. For this reason, IgM is the first immunoglobulin expressed by mature B-cells.\n\u003cbr\u003e \n\u003cbr\u003e IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes, and is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q. Clinically, hematuria and proteinuria are present, with or without nephrotic syndromes. Immunoglobulin M (IgM) nephropathy is an uncommon glomerular disease characterized by IgM deposits in the mesangium.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3080,3.0 mL,Tinto Predilute","offer_id":49735561249008,"sku":"BSB 3080","price":97.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3081,7.0 mL,Tinto Predilute","offer_id":49735561281776,"sku":"BSB 3081","price":158.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3082,15.0 mL,Tinto Predilute","offer_id":49735561314544,"sku":"BSB 3082","price":287.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3083,0.1 mL,Concentrate","offer_id":49735561347312,"sku":"BSB 3083","price":124.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3084,0.5 mL,Concentrate","offer_id":49735561380080,"sku":"BSB 3084","price":158.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3085,1.0 mL,Concentrate","offer_id":49735561412848,"sku":"BSB 3085","price":223.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3085.jpg?v=1778773357"},{"product_id":"pi5685","title":"IgM","description":"\u003cp\u003eIgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer or occasionally as a hexamer. It has a large molecular mass of approximately 900 kDa (in its pentamer form). In germline cells, the gene segment encoding the constant region of the heavy chain is positioned first among other constant region gene segments. For this reason, IgM is the first immunoglobulin expressed by mature B-cells.\n\u003cbr\u003e \n\u003cbr\u003e IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes, and is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5680,3.0 mL,Tinto Predilute","offer_id":49735561740528,"sku":"BSB 5680","price":103.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5681,7.0 mL,Tinto Predilute","offer_id":49735561773296,"sku":"BSB 5681","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5682,15.0 mL,Tinto Predilute","offer_id":49735561806064,"sku":"BSB 5682","price":299.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5683,0.1 mL,Concentrate","offer_id":49735561838832,"sku":"BSB 5683","price":130.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5684,0.5 mL,Concentrate","offer_id":49735561871600,"sku":"BSB 5684","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5685,1.0 mL,Concentrate","offer_id":49735561904368,"sku":"BSB 5685","price":233.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5685.jpg?v=1778773400"},{"product_id":"pi5706","title":"Kappa Light Chains","description":"\u003cp\u003eKappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin.\n\u003cbr\u003e \n\u003cbr\u003e When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio greater than or equal to 3:1, a lambda-kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5701,3.0 mL,Tinto Predilute","offer_id":49735568621808,"sku":"BSB 5701","price":122.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5702,7.0 mL,Tinto Predilute","offer_id":49735568654576,"sku":"BSB 5702","price":207.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5703,15.0 mL,Tinto Predilute","offer_id":49735568687344,"sku":"BSB 5703","price":366.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5704,0.1 mL,Concentrate","offer_id":49735568720112,"sku":"BSB 5704","price":130.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5705,0.5 mL,Concentrate","offer_id":49735568752880,"sku":"BSB 5705","price":246.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5706,1.0 mL,Concentrate","offer_id":49735568785648,"sku":"BSB 5706","price":349.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5706.jpg?v=1778774651"},{"product_id":"pi5720","title":"Lambda","description":"\u003cp\u003eLambda detects surface immunoglobulin on normal and neoplastic B-cells. Lambda staining is seen in B-cell follicles of human lymphoid tissue.\n\u003cbr\u003e \n\u003cbr\u003e When studying B-cell neoplasms, the determination of light chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda-positive cells. If only a single light-chain type is detected, a lymphoproliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio greater than or equal to 3:1, a lambda-kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5715,3.0 mL,Tinto Predilute","offer_id":49735572553968,"sku":"BSB 5715","price":122.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5716,7.0 mL,Tinto Predilute","offer_id":49735572586736,"sku":"BSB 5716","price":207.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5717,15.0 mL,Tinto Predilute","offer_id":49735572619504,"sku":"BSB 5717","price":366.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5718,0.1 mL,Concentrate","offer_id":49735572652272,"sku":"BSB 5718","price":130.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5719,0.5 mL,Concentrate","offer_id":49735572685040,"sku":"BSB 5719","price":246.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5720,1.0 mL,Concentrate","offer_id":49735572717808,"sku":"BSB 5720","price":349.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5720.jpg?v=1778828354"},{"product_id":"pi2075","title":"p40","description":"\u003cp\u003ep40 is an antibody that recognizes ΔNp63-a p63 isoform and it is highly specific for squamous\/basal cells. It may be a valuable marker in detecting Squamous Cell Carcinoma where p63 is currently used. It recognizes the shortest variant of p53. p40 is superior in specificity to p63 because it does not label lung adenocarcinomas like p63 does, which eliminates the potential of misinterpreting a positive adenocarcinoma as a squamous cell carcinoma.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 2070,3.0 mL,Predilute","offer_id":49735714177264,"sku":"BSB 2070","price":150.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2071,7.0 mL,Predilute","offer_id":49735714210032,"sku":"BSB 2071","price":287.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2072,15.0 mL,Predilute","offer_id":49735714242800,"sku":"BSB 2072","price":511.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2073,0.1 mL,Concentrate","offer_id":49735714275568,"sku":"BSB 2073","price":166.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2074,0.5 mL,Concentrate","offer_id":49735714308336,"sku":"BSB 2074","price":402.0,"currency_code":"USD","in_stock":true},{"title":"BSB 2075,1.0 mL,Concentrate","offer_id":49735714341104,"sku":"BSB 2075","price":620.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI2075.jpg?v=1778837658"},{"product_id":"pi3607","title":"p63","description":"\u003cp\u003eIn addition to p53, mammalian cells contain two homologous genes, p63 and p73. These genes give rise to the expression of proteins that are highly similar to p53 in structure and function. In particular, p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development.   Anti-p63 to human p63 protein labels an epitope common to all six p63 isotypes (TAp63α, TAp63β, TAp63γ, ΔNp63α, ΔNp63β, ΔNp63γ). p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 3602,3.0 mL,Tinto Predilute","offer_id":49735718142192,"sku":"BSB 3602","price":290.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3603,7.0 mL,Tinto Predilute","offer_id":49735718174960,"sku":"BSB 3603","price":525.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3604,15.0 mL,Tinto Predilute","offer_id":49735718207728,"sku":"BSB 3604","price":937.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3605,0.1 mL,Concentrate","offer_id":49735718240496,"sku":"BSB 3605","price":230.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3606,0.5 mL,Concentrate","offer_id":49735718273264,"sku":"BSB 3606","price":432.0,"currency_code":"USD","in_stock":true},{"title":"BSB 3607,1.0 mL,Concentrate","offer_id":49735718306032,"sku":"BSB 3607","price":757.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI3698_5235a697-0ccd-45ac-8f61-307e49ed5125.jpg?v=1785986748"},{"product_id":"pi5853","title":"p63","description":"\u003cp\u003eIn addition to p53, mammalian cells contain two homologous genes, p63 and p73. These genes give rise to the expression of proteins that are highly similar to p53 in structure and function. In particular, p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are more important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development.  Anti-p63 to human p63 protein labels an epitope common to all six p63 isotypes (TAp63α, TAp63β, TAp63γ, ΔNp63α, ΔNp63β, ΔNp63γ). p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.\u003c\/p\u003e","brand":"biosb","offers":[{"title":"BSB 5848,3.0 mL,Tinto Predilute","offer_id":49735720796400,"sku":"BSB 5848","price":320.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5849,7.0 mL,Tinto Predilute","offer_id":49735720829168,"sku":"BSB 5849","price":578.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5850,15.0 mL,Tinto Predilute","offer_id":49735720861936,"sku":"BSB 5850","price":1039.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5851,0.1 mL,Concentrate","offer_id":49735720894704,"sku":"BSB 5851","price":255.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5852,0.5 mL,Concentrate","offer_id":49735720927472,"sku":"BSB 5852","price":457.0,"currency_code":"USD","in_stock":true},{"title":"BSB 5853,1.0 mL,Concentrate","offer_id":49735720960240,"sku":"BSB 5853","price":802.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0686\/3660\/6704\/files\/PI5853.jpg?v=1778837826"},{"product_id":"pi2372","title":"PLA2R1","description":"\u003cp\u003ePLA2R1 gene encodes the phospholipase A2 receptor 1 protein, a 180 kDa transmembrane glycoprotein expressed by podocytes. Approximately 70% of patients with idiopathic membranous glomerulopathy have autoantibodies directed against PLA2R1. \n\u003cbr\u003e  PLA2R1 also promotes tumor suppressive responses including senescence, apoptosis, and inhibition of transformation. Known oncogenes such as HIF2α and c-Myc repress PLA2R1 expression.\n\u003cbr\u003e  Supporting a tumor suppressive role of PLA2R1, its expression decreases in numerous cancers, and known oncogenes such as HIF2α and c-MYC repress its expression. PLA2R1 promoter methylation, a classical way to repress tumor suppressive gene expression in cancer cells, is observed in leukemia, in the kidney and in breast cancer cells. Mechanistically, PLA2R1 activates the kinase JAK2 and orients its activity towards a tumor suppressive one. 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