IHC of Villin on an FFPE Colon Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
Villin is an actin-binding protein that contains gelsolin domains capped by a ”headpiece” consisting of a fast and independently-folding three-helix bundle stabilized by hydrophobic interactions. The headpiece domain is a commonly-studied protein in molecular dynamics due to its fast-folding kinetics and short primary sequence. It is a regulator of the actin cytoskeleton and is expressed mainly in the brush border of the GI mucosal epithelium in animals.
Anti-Villin labels the brush border area in the gastrointestinal mucosal epithelium. This antibody has been useful in differentiating Gastrointestinal Adenocarcinoma, Neuroendocrine Carcinomas and Ovarian Adenocarcinomas from Adenocarcinomas of other organs. Also labeled by this antibody are Merkel cells of the skin.
|Antibody Type||Rabbit Monoclonal||Clone||EP 163|
|Localization||Cytoplasmic, Membranous||Control||Kidney, Colon, Small Bowel Mucosa, Colonic Mucosa|
|Presentation||Villin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|