IHC of VEGF on an FFPE Placenta Tissue

VEGF Antibody Immunohistochemistry on an FFPE Kidney Tissue

United States
International
Research Use
Safety Data Sheet
Control Slides
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). As its name implies, VEGF activity is restricted mainly to cells of the vascular endothelium, although it has an effect on a limited number of other cell types (e.g., stimulation monocyte/macrophage migration).

VEGF antibody expression has been implicated with poor prognosis in breast cancer. The overexpression of VEGF may be an early step in the process of metastasis, a step involved in the “angiogenic” switch. Although VEGF has been correlated with poor survival, its exact mechanism of action in the progression of tumors remains unclear. VEGF is also released in rheumatoid arthritis in response to TNF-alpha, increasing endothelial permeability and swelling and also stimulating angiogenesis (formation of capillaries). Once released, VEGF may elicit several responses. It may cause a cell to survive, move, or further differentiate.

Antibody TypeRabbit MonoclonalCloneRBT-VEGF
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, Cell SurfaceControlPlacenta, Angiosarcoma, Angioma
PresentationVEGF is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6050PredilutedReady-To-Use3.0 ml
BSB 6051PredilutedReady-To-Use7.0 ml
BSB 6052PredilutedReady-To-Use15.0 ml
BSB 6053Concentrated1:10-1:500.1 ml
BSB 6054Concentrated1:10-1:500.5 ml
BSB 6055Concentrated1:10-1:501.0 ml
BSB 6056Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: anti-VEGF, anti VEGF, anti VEGFA, anti-VEGFA, MGC70609, MVCD1, vascular endothelial growth factor A, vascular permeability factor, VEGF, VEGF A, VPF, C1, C 1