TNFa-IP2 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
Tumor Necrosis Factor alpha Induced-Protein 2 (also known as B94) is a 73‐kDa polypeptide involved in pathways of inflammation, metastasis, tumor vasculature, and angiogenesis. The protein has an exocyst complex, Dsl1 complex, conserved oligomeric Golgi (COG) complex and the Golgi‐associated retrograde protein (GARP) complex.
TNFa-IP2 antibody expression is found in epithelial cells, and immune cells exposed to Tumor Necrosis Factor alpha (TNFa), IL-1beta, LPS, interferon-y, Retinoic Acid, Latent Membrane Protein 1 (LMP1), and other pro-inflammatory cytokines. TNFaIP can inhibit NFKB to further reduce inflammation in renal dysfunction and septic shock. and can interact with GTPases to regulate breast cancer and HeLa cell actin cytoskeleton and cell structure. TNFaIP2 also participates in T-cell migration as an inflammatory regulator of chemokine secretion, and promotes metastasis and microvessel formation in nasopharyngeal carcinoma.
|Antibody Type||Mouse Monoclonal||Clone||BSB-141|
|Localization||Cytoplasmic, Membranous||Control||Testis, Tonsil, Lung, Kidney|
|Presentation||TNFa-IP2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|