TMPRSS2 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
Transmembrane Serine Protease 2 is part of the serine protease family, which is active in many physiological and pathological pathways. TMPRSS2 is a 492 amino acid protein, containing a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain, and a protease domain. It is upregulated by androgen hormones particularly in the prostate, where it may contribute to inflammation by activating PAR2 and prostate cancer through somatic rearrangement. TMPRSS2 antibody is also expressed in the GI tract, stomach, kidney and in the lung epithelium, where it may cleave epithelial sodium channels. The TMPRSS2-ERG fusion pair is a common somatic gene rearrangement occurring in about 50% of primary prostate cancers.
TMPRSS2 antibody positive tumors may be at higher risk for metastasis and influence from hormones, with a different androgen metabolism and higher insulin signaling than negative tumors. The protease domain also proteolytically cleaves and activates viral envelope glycoproteins, facilitating the cellular entry of human influenza and coronaviruses such as SARS-CoV-2.
|Antibody Type||Mouse Monoclonal||Clone||BSB-136|
|Localization||Nuclear, Membranous||Control||Testis, Colon, Kidney, Brain, Stomach. Pancreas, Prostate|
|Presentation||TMPRSS2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|