tdp43, tdp-43, tdp 43, anti-tdp43, anti-tdp-43, anti-tdp 43, tardbp, anti-tardbp, transactive response dna binding protein 43

TDP-43 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue

Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Transactive Response DNA binding protein 43 (TPD-43 or TARDBP) is an RNA and DNA binding protein in the heterogeneous nuclear ribonucleoprotein (hnRNP) family, where it regulates RNA associated with glucose and lipid metabolism.

TDP-43 antibody expression (TARDBP antibody) is associated with several neurodegenerative conditions amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and metabolic regulation in cancer cells. TDP-43/TARDBP regulation of miRNAs has both tumor supporting and suppressive roles. Upregulation of TDP-43/TARDBP can lead to continued autophagy for survival and suppression of apoptosis pathways, promoting cancer cell survival under conditions of nutrient stress, as was seen in a study of glioblastomas. TDP-43/TARDBP and its targeted miRNAs have been associated with increased cell growth and migration in hepatocellular and lung cancers, but also with tumor inhibition in rhabdomyosarcomas through miRNA miR-500a-3p. TDP-43/TARDBP may also influence the function and targets of MiR-152, and miRNA associated with hepatocellular carcinoma, endometrial, gastric, and ovarian cancers. TDP-43/TARDBP has been found to be a novel oncogene in melanoma and regulates melanoma proliferation and metastasis potentially through modulation of glucose metabolism. TDP-43, has been found to promote triple-negative breast cancer (TNBC) progression.

Antibody TypeMouse MonoclonalCloneBSB-166
IsotypeIgG2aReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlBreast, Fallopian Tube, Tstis, Skin, Transition Call Carcinoma, Glioblastoma
PresentationTDP-43 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3776-3PredilutedReady-To-Use3.0 ml
BSB-3776-7PredilutedReady-To-Use7.0 ml
BSB-3776-15PredilutedReady-To-Use15.0 ml
BSB-3776-01Concentrated1:50-1:2000.1 ml
BSB-3776-05Concentrated1:50-1:2000.5 ml
BSB-3776-1Concentrated1:50-1:2001.0 ml
BSB-3776-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: tdp43, tdp-43, tdp 43, anti-tdp43, anti-tdp-43, anti-tdp 43, tardbp, anti-tardbp, transactive response dna binding protein 43