TDP-43 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
Transactive Response DNA binding protein 43 (TPD-43 or TARDBP) is an RNA and DNA binding protein in the heterogeneous nuclear ribonucleoprotein (hnRNP) family, where it regulates RNA associated with glucose and lipid metabolism.
TDP-43 antibody expression (TARDBP antibody) is associated with several neurodegenerative conditions amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and metabolic regulation in cancer cells. TDP-43/TARDBP regulation of miRNAs has both tumor supporting and suppressive roles. Upregulation of TDP-43/TARDBP can lead to continued autophagy for survival and suppression of apoptosis pathways, promoting cancer cell survival under conditions of nutrient stress, as was seen in a study of glioblastomas. TDP-43/TARDBP and its targeted miRNAs have been associated with increased cell growth and migration in hepatocellular and lung cancers, but also with tumor inhibition in rhabdomyosarcomas through miRNA miR-500a-3p. TDP-43/TARDBP may also influence the function and targets of MiR-152, and miRNA associated with hepatocellular carcinoma, endometrial, gastric, and ovarian cancers. TDP-43/TARDBP has been found to be a novel oncogene in melanoma and regulates melanoma proliferation and metastasis potentially through modulation of glucose metabolism. TDP-43, has been found to promote triple-negative breast cancer (TNBC) progression.
|Antibody Type||Mouse Monoclonal||Clone||BSB-166|
|Localization||Cytoplasmic, Nuclear||Control||Breast, Fallopian Tube, Tstis, Skin, Transition Call Carcinoma, Glioblastoma|
|Presentation||TDP-43 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|