T-bet

T-Bet Antibody Immunohistochemistry on an FFPE Lymphoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T cells to Th1 development.

T-bet antibody is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pregerminal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for T-bet. Therefore, T-bet antibody should serve as a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders.

Antibody TypeRabbit MonoclonalCloneEP263
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlSpleen, Tonsil, Cervix, Lymphoblastic lymphoma, Hairy Cel leukemia, Bladder TCC
PresentationT-bet is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2601PredilutedReady-To-Use3.0 ml
BSB 2602PredilutedReady-To-Use7.0 ml
BSB 2603PredilutedReady-To-Use15.0 ml
BSB 2604Concentrated1:25-1:1000.1 ml
BSB 2605Concentrated1:25-1:1000.5 ml
BSB 2606Concentrated1:25-1:1001.0 ml
BSB 2607Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: T bet, Tbet, Tbx21, anti-T-bet, anti T-bet, anti-T bet, anti-Tbet, anti T bet, anti Tbet, anti-TBX21, anti TBX21, T box 21, T box expressed in T cells, T box protein 21, T box transcription factor TBX21, T cell specific T box transcription factor, T cell specific T box transcription factor T bet, T PET, Tblym, transcription factor TBLYM, TBT1