IHC of STAR on an FFPE Adrenal Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Steroidogenic acute regulatory protein (STAR) is a protein that in humans is encoded by the STAR gene. The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane.

STAR is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Low level of STAR expression in other tissues that produce steroid hormones for local use have been reported. STAR is a sensitive and specific marker for Leydig cell tumor. It is useful for differential diagnosis of sex-cord stromal tumor (SCST). Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH.

Antibody Type Rabbit Monoclonal Clone EP226
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Leydig Cells of Testis, Adrenal & Leydig Cell Tumors
Presentation STAR is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3630 Prediluted Ready-To-Use 3.0 ml
BSB 3631 Prediluted Ready-To-Use 7.0 ml
BSB 3632 Prediluted Ready-To-Use 15.0 ml
BSB 3633 Concentrated 1:50-1:200 0.1 ml
BSB 3634 Concentrated 1:50-1:200 0.5 ml
BSB 3635 Concentrated 1:50-1:200 1.0 ml
BSB 3636 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.